Gastroenterology
Volume 138, Issue 3 , Pages 905-912 , March 2010

HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

  • Luca Valenti

      Affiliations

    • Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Anna Ludovica Fracanzani

      Affiliations

    • Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Elisabetta Bugianesi

      Affiliations

    • Department of Gastroenterology, Università di Torino, Torino, Italy
    • ,
  • Paola Dongiovanni

      Affiliations

    • Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Enrico Galmozzi

      Affiliations

    • Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Ester Vanni

      Affiliations

    • Department of Gastroenterology, Università di Torino, Torino, Italy
    • ,
  • Elena Canavesi

      Affiliations

    • Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Ezio Lattuada

      Affiliations

    • Department of Surgery, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Giancarlo Roviaro

      Affiliations

    • Department of Surgery, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • ,
  • Giulio Marchesini

      Affiliations

    • Department of Internal Medicine, Università Alma Mater Bologna, Bologna, Italy
    • ,
  • Silvia Fargion

      Affiliations

    • Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    • Corresponding Author InformationReprint requests Address requests for reprints to: S. Fargion, MD, Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italia. fax: (39) 02-50320296

Received 10 September 2009 ,Accepted 12 November 2009.

References 

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 This article has an accompanying continuing medical education activity on page e9. Learning Objective: Upon completion of reading this article, successful learners will be able to differentiate the effect of different patterns of iron overload on liver damage, understand the effect of mutations in the HFE gene of hereditary hemochromatosis in determining the predisposition to develop iron overload, and recognize the lack of utility of HFE mutations assessment in the absence of histological demonstration of hepatocellular iron accumulation in patients with nonalcoholic fatty liver disease.

 View this article's video abstract at www.gastrojournal.org.

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the following grants: FIRST Università di Milano 2007, 2008 (to L.V., S.F., A.L.F.); Ricerca corrente Ospedale Maggiore Policlinico 2006 and 2008 (L.V., S.F.); and Centro per lo Studio delle Malattie del Fegato e del Metabolismo.

PII: S0016-5085(09)02003-4

doi: 10.1053/j.gastro.2009.11.013

Gastroenterology
Volume 138, Issue 3 , Pages 905-912 , March 2010

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