Gastroenterology
Volume 138, Issue 3 , Pages 993-1002.e1 , March 2010

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

  • Melanie H. Kucherlapati

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests Address requests for reprints to: Melanie Kucherlapati, PhD, Department of Medicine/Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115. or Winfried Edelmann, PhD, Department of Cell Biology, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, New York 10461
    • ,
  • Kyeryoung Lee

      Affiliations

    • Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
    • ,
  • Andrew A. Nguyen

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Alan B. Clark

      Affiliations

    • Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina
    • Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina
    • ,
  • Harry Hou Jr

      Affiliations

    • Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
    • ,
  • Andrew Rosulek

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Hua Li

      Affiliations

    • Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York
    • ,
  • Kan Yang

      Affiliations

    • Strang Cancer Research Laboratory, Department of Medicine (Gastroenterology), Weill Medical Center of Cornell University, New York, New York
    • ,
  • Kunhua Fan

      Affiliations

    • Strang Cancer Research Laboratory, Department of Medicine (Gastroenterology), Weill Medical Center of Cornell University, New York, New York
    • ,
  • Martin Lipkin

      Affiliations

    • Strang Cancer Research Laboratory, Department of Medicine (Gastroenterology), Weill Medical Center of Cornell University, New York, New York
    • ,
  • Roderick T. Bronson

      Affiliations

    • Rodent Histopathology Core, Harvard Medical School, Boston, Massachusetts
    • Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, Massachusetts
    • ,
  • Linda Jelicks

      Affiliations

    • Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York
    • ,
  • Thomas A. Kunkel

      Affiliations

    • Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina
    • Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina
    • ,
  • Raju Kucherlapati

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Winfried Edelmann

      Affiliations

    • Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York

Received 21 August 2009 ,Accepted 10 November 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by NIH grants ES11040 (to R.K.), CA084301 (to R.K.), CA76329 (to W.E.), and CA93484 (to W.E.); Center grant CA13330 (to Albert Einstein College of Medicine); and Project Z01 ES065089, Division of Intramural Research of the NIH, NIEHS (to T.A.K.).

PII: S0016-5085(09)01999-4

doi: 10.1053/j.gastro.2009.11.009

Gastroenterology
Volume 138, Issue 3 , Pages 993-1002.e1 , March 2010

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