« Previous
Next »
Gastroenterology
Volume 138, Issue 3
, Pages 1155-1165.e2
, March 2010
Induction of p53 Renders ATM-Deficient Mice Refractory to Hepatocarcinogenesis
References
- . Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–2576
- Focus on hepatocellular carcinoma. Cancer Cell. 2004;215–219
- . Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer. 2006;6:674–687
- Clonal analysis of precancerous lesions of hepatocellular carcinoma. Gastroenterology. 1996;111:455–461
- M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet. 1995;11:447–449
- . DNA double-strand breaks: signalling, repair and the cancer connection. Nat Genet. 2001;27:247–254
- . Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet. 2001;2:196–206
- Defective Ku70 DNA double strand break repair enhances hepatocarcinogenesis in mice. Hepatology. 2008;47:2078–2088
- Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration. J Biol Chem. 1994;269:2491–2500
- Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage. Hepatology. 2009;50:500
- . Live or let die: the cell's response to p53. Nat Rev Cancer. 2002;2:594–604
- . ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 2003;3:155–168
- . ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001;21:4129–4139
- ATR and ATRiP: partners in checkpoint signalling. Science. 2001;294:1713–1716
- . A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat Cell Biol. 1999;1:393–398
- Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double strand breaks. Science. 1999;286:1162–1166
- . Genome scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction and identification of therapeutic targets. Gastroenterology. 2004;127:S51–S55
- atm and p53 Cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet. 1997;16:397–401
- Senescence and tumor clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007;445:656–660
- Restoration of p53 leads to tumor regression in vivo. Nature. 2007;445:661–665
- Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999;21:111–114
- . Telomeres and telomerase: a dual role in hepatocarcinogenesis. Hepatology. 2004;40:276–283
- Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2003;421:643–647
Conflicts of interest The authors disclose no conflicts.
Funding Supported by the Australian NHMRC project grant No. 418100, NHMRC program grant No. 358398, NIH grant CA No. 74131, and ACS grant No. RSG-04-019-01-CNE.
PII: S0016-5085(09)01998-2
doi: 10.1053/j.gastro.2009.11.008
© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 138, Issue 3
, Pages 1155-1165.e2
, March 2010

