Gastroenterology
Volume 138, Issue 3 , Pages 843-853.e2 , March 2010

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

Received 26 June 2009 ,Accepted 4 November 2009.

References 

  1. Ballinger A. Adverse effects of nonsteroidal anti-inflammatory drugs on the colon. Curr Gastroenterol Rep. 2008;10:485–489
  2. Langan RC, Gotsch PB, Krafczyk MA, et al. Ulcerative colitis: diagnosis and treatment. Am Fam Physician. 2007;76:1323–1330
  3. Truelove SC. Systemic and local corticosteroid therapy in ulcerative colitis. Br Med J. 1960;1:464–467
  4. Reshef R, Varkel J, Shiller M, et al. Systemic effects of rectally administered corticosteroids. Isr J Med Sci. 1992;28:98–100
  5. Hebrard G, Hoffart V, Cardot J, et al. Investigation of coated whey protein/alginate beads as sustained release dosage form in simulated gastrointestinal environment. Drug Dev Ind Pharm. 2009;14:1–10
  6. Lamprecht A, Yamamoto H, Takeuchi H, et al. A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles. J Control Release. 2005;104:337–346
  7. Lamprecht A, Yamamoto H, Takeuchi H, et al. Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats. J Pharmacol Exp Ther. 2005;315:196–202
  8. Leserman LD, Machy P, Barbet J. Cell-specific drug transfer from liposomes bearing monoclonal antibodies. Nature. 1981;293:226–228
  9. Laroui H, Grossin L, Leonard M, et al. Hyaluronate-covered nanoparticles for the therapeutic targeting of cartilage. Biomacromolecules. 2007;8:3879–3885
  10. Makhlof A, Tozuka Y, Takeuchi H. pH-sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model. Eur J Pharm Biopharm. 2009;72:1–8
  11. Meissner Y, Pellequer Y, Lamprecht A. Nanoparticles in inflammatory bowel disease: particle targeting versus pH-sensitive delivery. Int J Pharm. 2006;316:138–143
  12. Feng SS, Mei L, Anitha P, et al. Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel. Biomaterials. 2009;30:3297–3306
  13. Yang H, Li K, Liu Y, et al. Poly(D,L-lactide-co-glycolide) nanoparticles encapsulated fluorescent isothiocyanate and paclitaxol: preparation, release kinetics and anticancer effect. J Nanosci Nanotechnol. 2009;9:282–287
  14. Fukui H, Murakami M, Yoshikawa H, et al. Studies on the promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles (Dependence on particle size and administration site). J Pharmacobiodyn. 1987;10:236–242
  15. Kitajima S, Takuma S, Morimoto M. Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium. Exp Anim. 1999;48:137–143
  16. Lamprecht A, Schafer U, Lehr CM. Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res. 2001;18:788–793
  17. Bachmanov AA, Reed DR, Beauchamp GK, et al. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet. 2002;32:435–443
  18. Dalmasso G, Charrier-Hisamuddin L, Thu Nguyen HT, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134:166–178
  19. Brzoska T, Luger TA, Maaser C, et al. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. 2008;29:581–602
  20. Kannengiesser K, Maaser C, Heidemann J, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14:324–331
  21. Burd DA, Greco RM, Regauer S, et al. Hyaluronan and wound healing: a new perspective. Br J Plast Surg. 1991;44:579–584
  22. Yotsuyanagi T, Ohkubo T, Ohhashi T, et al. Calcium-induced gelation of alginic acid and pH-sensitive reswelling of dried gels. Chem Pharm Bull. 1987;35:1555–1563
  23. Garcia AM, Ghaly ES. Preliminary spherical agglomerates of water soluble drug using natural polymer and cross-linked technique. J Control Release. 1996;40:179–186
  24. Clayton HA, London NJ, Colloby PS, et al. The effect of capsule composition on the biocompatibility of alginate-poly-l-lysine capsules. J Microencapsul. 1991;8:221–233
  25. Azab AK, Orkin B, Doviner V, et al. Crosslinked chitosan implants as potential degradable devices for brachytherapy: in vitro and in vivo analysis. J Control Release. 2006;111:281–289
  26. Tozaki H, Odoriba T, Okada N, et al. Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. J Control Release. 2002;82:51–61
  27. Mladenovska K, Raicki RS, Janevik EI, et al. Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles. Int J Pharm. 2007;342:124–136
  28. Shi C, Zhu Y, Ran X, et al. Therapeutic potential of chitosan and its derivatives in regenerative medicine. J Surg Res. 2006;133:185–192
  29. Xiao C, Luong JH. Assessment of cytotoxicity by emerging impedance spectroscopy. Toxicol Appl Pharmacol. 2005;206:102–112
  30. Jain KK. The role of nanobiotechnology in drug discovery. Drug Discov Today. 2005;10:1435–1442
  31. Lamprecht A. Multiparticulate systems in the treatment of inflammatory bowel disease. Curr Drug Targets Inflamm Allergy. 2003;2:137–144
  32. Bertholon I, Ponchel G, Labarre D, et al. Bioadhesive properties of poly(alkylcyanoacrylate) nanoparticles coated with polysaccharide. J Nanosci Nanotechnol. 2006;6:3102–3109
  33. Hillaireau H, Le Doan T, Chacun H, et al. Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers. Int J Pharm. 2007;331:148–152
  34. Nugent SG, Kumar D, Rampton DS, et al. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut. 2001;48:571–577
  35. Luger TA, Scholzen TE, Brzoska T, et al. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann N Y Acad Sci. 2003;994:133–140
  36. Sogias IA, Williams AC, Khutoryanskiy VV. Why is chitosan mucoadhesive?. Biomacromolecules. 2008;9:1837–1842

 Conflicts of interest The authors disclose no conflicts.

 Funding This work was supported by National Institutes of Health of Digestive Diseases Research center grant (R24-DK-064399), R56-DK061941 (D.M.), RO1-DK076825 and RO1-DK064711 (S.V.S.); and a research fellowship award from the Crohn's and Colitis Foundation of America (G.D.).

PII: S0016-5085(09)01962-3

doi: 10.1053/j.gastro.2009.11.003

Gastroenterology
Volume 138, Issue 3 , Pages 843-853.e2 , March 2010

Article Tools

* Image Usage & Resolution