Gastroenterology
Volume 138, Issue 2 , Pages 550-561.e8 , February 2010

Loss of Parietal Cell Expression of Sonic Hedgehog Induces Hypergastrinemia and Hyperproliferation of Surface Mucous Cells

  • Chang Xiao

      Affiliations

    • Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Sally A. Ogle

      Affiliations

    • Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Michael A. Schumacher

      Affiliations

    • Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Melissa A. Orr–Asman

      Affiliations

    • Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Marian L. Miller

      Affiliations

    • Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Nantaporn Lertkowit

      Affiliations

    • The Physiological Laboratory, School of Biomedical Sciences, Crown Street, University of Liverpool, Liverpool, England
    • ,
  • Andrea Varro

      Affiliations

    • The Physiological Laboratory, School of Biomedical Sciences, Crown Street, University of Liverpool, Liverpool, England
    • ,
  • Frederic Hollande

      Affiliations

    • CNRS UMR5203, Montpellier, France
    • INSERM Unité 661, Montpellier, France
    • Université Montpellier I, Montpellier, France
    • Université Montpellier II, Montpellier, France
    • Cellular and Molecular Oncology Department, Institut de Génomique Fonctionnelle, Montpellier, France
    • ,
  • Yana Zavros

      Affiliations

    • Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • Corresponding Author InformationReprint requests Address requests for reprints to: Yana Zavros, PhD, Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert B. Sabin Way, Room 4259A, MSB, Cincinnati, Ohio 45267-0576. fax: (513) 558-5738

Received 5 September 2008 ,Accepted 5 November 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by start-up funds (Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH) and from the Digestive Health Center Cincinnati Children's Medical Health Center (DHC: Bench to Bedside Research in Pediatric Digestive Disease) Pilot and Feasibility Project Award CHTF/SUB DK078392 (to Y.Z.).

PII: S0016-5085(09)01959-3

doi: 10.1053/j.gastro.2009.11.002

Gastroenterology
Volume 138, Issue 2 , Pages 550-561.e8 , February 2010

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