Gastroenterology
Volume 138, Issue 2 , Pages 487-492 , February 2010

Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands

  • Lisette G. Capelle

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    • Corresponding Author InformationReprint requests Address requests for reprints to: Lisette G. Capelle, MD, Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Room L-462, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. fax: +31 (0)10703279
  • ,
  • Nicole C.T. Van Grieken

      Affiliations

    • Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
  • ,
  • Hester F. Lingsma

      Affiliations

    • Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands
  • ,
  • Ewout W. Steyerberg

      Affiliations

    • Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands
  • ,
  • Willem J. Klokman

      Affiliations

    • Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • ,
  • Marco J. Bruno

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
  • ,
  • Hans F.A. Vasen

      Affiliations

    • The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands
    • Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
  • ,
  • Ernst J. Kuipers

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    • Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands

Received 5 June 2009 ,Accepted 26 October 2009.

References 

  1. Lynch HT, Smyrk TC, Watson P, et al. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology. 1993;104:1535–1549
  2. Vasen HF. The Lynch syndrome (hereditary nonpolyposis colorectal cancer). Aliment Pharmacol Ther. 2007;26(Suppl 2):113–126
  3. Peltomaki P, Vasen H. Mutations associated with HNPCC predisposition—update of ICG-HNPCC/INSiGHT mutation database. Dis Markers. 2004;20:269–276
  4. Koornstra JJ, Mourits MJ, Sijmons RH, et al. Management of extracolonic tumours in patients with Lynch syndrome. Lancet Oncol. 2009;10:400–408
  5. Vasen HF, Moslein G, Alonso A, et al. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet. 2007;44:353–362
  6. Watson P, Lynch HT. The tumor spectrum in HNPCC. Anticancer Res. 1994;14:1635–1639
  7. Watson P, Lynch HT. Extracolonic cancer in hereditary nonpolyposis colorectal cancer. Cancer. 1993;71:677–685
  8. Aarnio M, Salovaara R, Aaltonen LA, et al. Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome. Int J Cancer. 1997;74:551–555
  9. Maul JS, Warner NR, Kuwada SK, et al. Extracolonic cancers associated with hereditary nonpolyposis colorectal cancer in the Utah Population Database. Am J Gastroenterol. 2006;101:1591–1596
  10. Bermejo JL, Eng C, Hemminki K. Cancer characteristics in Swedish families fulfilling criteria for hereditary nonpolyposis colorectal cancer. Gastroenterology. 2005;129:1889–1899
  11. Warthin AS. Heredity with reference to carcinoma. Arch Intern Med. 1913;9:279–296
  12. Vasen HF, den Hartog Jager FC, Menko FH, et al. Screening for hereditary non-polyposis colorectal cancer: a study of 22 kindreds in The Netherlands. Am J Med. 1989;86:278–281
  13. Breslow N, Day N. Statistical methods in cancer research: Volume II: the design and analysis of cohort studies. IARC Sci Publ. 1987;82:1–406
  14. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49
  15. Lynch HT, Krush AJ. Cancer family “G” revisited: 1895–1970. Cancer. 1971;27:1505–1511
  16. Lynch HT, Lynch JF. Lynch syndrome: history and current status. Dis Markers. 2004;20:181–198
  17. www.ikcnet.nl2006;Accessed 2009
  18. Park YJ, Shin KH, Park JG. Risk of gastric cancer in hereditary nonpolyposis colorectal cancer in Korea. Clin Cancer Res. 2000;6:2994–2998
  19. Park JG, Park YJ, Wijnen JT, et al. Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. Int J Cancer. 1999;82:516–519
  20. Aarnio M, Sankila R, Pukkala E, et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer. 1999;81:214–218
  21. Watson P, Vasen HF, Mecklin JP, et al. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer. 2008;123:444–449
  22. Jager AC, Bisgaard ML, Myrhoj T, et al. Reduced frequency of extracolonic cancers in hereditary nonpolyposis colorectal cancer families with monoallelic hMLH1 expression. Am J Hum Genet. 1997;61:129–138
  23. Vasen HF, Stormorken A, Menko FH, et al. MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. J Clin Oncol. 2001;19:4074–4080
  24. Geary J, Sasieni P, Houlston R, et al. Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). Fam Cancer. 2008;7:163–172
  25. Kastrinos F, Stoffel EM, Balmana J, et al. Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States. Cancer Epidemiol Biomarkers Prev. 2008;17:2044–2051
  26. Wijnen J, de Leeuw W, Vasen H, et al. Familial endometrial cancer in female carriers of MSH6 germline mutations. Nat Genet. 1999;23:142–144
  27. Wu Y, Berends MJ, Mensink RG, et al. Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations. Am J Hum Genet. 1999;65:1291–1298
  28. ten Kate GL, Kleibeuker JH, Nagengast FM, et al. Is surveillance of the small bowel indicated for Lynch syndrome families?. Gut. 2007;56:1198–1201
  29. Hendriks YM, de Jong AE, Morreau H, et al. Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians. CA Cancer J Clin. 2006;56:213–225
  30. Lindor NM, Petersen GM, Hadley DW, et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review. JAMA. 2006;296:1507–1517
  31. Ziogas A, Anton-Culver H. Validation of family history data in cancer family registries. Am J Prev Med. 2003;24:190–198
  32. Gylling A, Abdel-Rahman WM, Juhola M, et al. Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? (A molecular genetic study). Gut. 2007;56:926–933
  33. Goecke T, Schulmann K, Engel C, et al. Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. J Clin Oncol. 2006;24:4285–4292

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)01948-9

doi: 10.1053/j.gastro.2009.10.051

Gastroenterology
Volume 138, Issue 2 , Pages 487-492 , February 2010