Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands

Capelle, Lisette G.; Van Grieken, Nicole C.T.; Lingsma, Hester F.; Steyerberg, Ewout W.; Klokman, Willem J.; Bruno, Marco J.; Vasen, Hans F.A.; Kuipers, Ernst J.

doi:10.1053/j.gastro.2009.10.051

« Previous Next »Gastroenterology
Volume 138, Issue 2 , Pages 487-492, February 2010

Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands

Lisette G. Capelle
- Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
- Reprint requests Address requests for reprints to: Lisette G. Capelle, MD, Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Room L-462, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. fax: +31 (0)10703279
Nicole C.T. Van Grieken
- Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Hester F. Lingsma
- Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Ewout W. Steyerberg
- Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Willem J. Klokman
- Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Marco J. Bruno
- Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Hans F.A. Vasen
- The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands
- Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
Ernst J. Kuipers
- Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
- Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands

Received 5 June 2009; accepted 26 October 2009. published online 09 November 2009.

Background & Aims

Although gastric cancer forms part of the Lynch syndrome tumor spectrum, the risk of developing gastric cancer in Lynch syndrome families is unknown, resulting in a lack of clear guidelines for surveillance. The aim of this study was to evaluate incidence trends and risk of developing gastric cancer among Lynch syndrome mutation carriers in a Western population.

Methods

Lynch syndrome mutation carriers were selected from the Dutch Hereditary Cancer Registry. The gastric cancer incidence in Lynch syndrome mutation carriers was compared to the gastric cancer incidence in the Dutch population between 1970 and 2003. Standardized incidence ratios were calculated by a Poisson model. Cumulative risks were calculated by Kaplan-Meier analysis.

Results

Overall, 2014 Lynch syndrome mutation carriers were identified. Gastric cancer was diagnosed in 32 (1.6%) subjects (male/female: 21/11), 22 (69%) of them had a negative family history of gastric cancer. The standardized incidence ratios of gastric cancer was 3.4 (95% confidence interval, 2.1–5.2) and showed a nonsignificant decline between 1970 and 2003 (P = .30). Absolute risk of developing gastric cancer also showed no significant change over time (P = .51). Lifetime risk of developing gastric cancer was 8.0% in males vs 5.3% in females (P = .02), and 4.8% and 9% for MLH1 and MSH2 carriers, respectively. None of the 378 MSH6 carriers developed gastric cancer (P = .002 vs MLH1 and MSH2 combined lifetime risk).

Conclusions

Lynch syndrome mutation carriers have a substantial risk for gastric cancer, in particular patients with an MLH1 or MSH2 mutation. Family history for gastric cancer is a poor indicator for individual risk. Surveillance gastroscopy for Lynch syndrome patients carrying an MLH1 or MSH2 mutation should therefore be considered.

Abbreviations used in this paper: CI, confidence interval, SIR, standardized incidence rate