Gastroenterology
Volume 138, Issue 2 , Pages 726-737, February 2010

Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice

  • Thomas Wartmann

      Affiliations

    • Division of Experimental Surgery, Department of Surgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany
    • ,
  • Julia Mayerle

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Thilo Kähne

      Affiliations

    • Institute of Experimental Internal Medicine, Department of Internal Medicine, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany
    • ,
  • Miklós Sahin–Tóth

      Affiliations

    • Department of Molecular and Cell Biology, Boston University, Goldman School of Dental Medicine, Boston, Massachusetts
    • ,
  • Manuel Ruthenbürger

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Rainer Matthias

      Affiliations

    • Division of Experimental Surgery, Department of Surgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany
    • ,
  • Anne Kruse

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Thomas Reinheckel

      Affiliations

    • Institut für Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany
    • ,
  • Christoph Peters

      Affiliations

    • Institut für Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany
    • ,
  • F. Ulrich Weiss

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Matthias Sendler

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Hans Lippert

      Affiliations

    • Division of Experimental Surgery, Department of Surgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany
    • ,
  • Hans–Ulrich Schulz

      Affiliations

    • Division of Experimental Surgery, Department of Surgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany
    • ,
  • Ali Aghdassi

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Annegret Dummer

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Steffen Teller

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • ,
  • Walter Halangk

      Affiliations

    • Division of Experimental Surgery, Department of Surgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany
    • ,
  • Markus M. Lerch

      Affiliations

    • Department of Medicine A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
    • Corresponding Author InformationReprint requests Address requests for reprints to: Markus M. Lerch, MD, Department of Medicine A, Ernst-Moritz-Arndt-University, Greifswald Friedrich-Loeffler-Strasse 23A, D-17475 Greifswald, Germany. fax: (49) 3834-867234

Received 17 April 2009; accepted 9 October 2009. published online 09 November 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by grants from the Deutsche Forschungsgemeinschaft DFG HA2080/7-1, LE 625/8-1, LE 625/9-1, MA4115/1-2, DFG GRK 840 E3 and E4; Mildred Scheel Stiftung 10-2031-Le I and 10-6977-Re, BMBF-NBL3 01 ZZ 0403; and Alfried-Krupp Foundation (Graduiertenkolleg Tumorbiologie) and NIH DK058088 to MST.

PII: S0016-5085(09)01945-3

doi:10.1053/j.gastro.2009.10.048

Gastroenterology
Volume 138, Issue 2 , Pages 726-737, February 2010

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