« Previous
Next »
Gastroenterology
Volume 138, Issue 2
, Pages 627-635
, February 2010
CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium
References
- . Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell. 1987;48:465–478
- . The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther. 2004;7:593–601
- . Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995;83:641–653
- Homeosis and intestinal tumours in Cdx2 mutant mice. Nature. 1997;386:84–87
- Cdx4 mutants fall to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003;425:300–306
- The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2005;133:419–428
- Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development. 2002;129:2181–2193
- Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell. 2005;123:917–929
- Cdx1 and Cdx2 expression during intestinal development. Gastroenterology. 2000;119:961–971
- . Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell. 2009;16:588–599
- Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res. 1999;59:2965–2970
- Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A. 1995;92:4482–4486
- Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2+/− compound mutant mice. Nat Genet. 2003;35:323–330
- Surprising versatility of Na+-glucose cotransporters: SLC5. Physiology. 2004;19:370–376
- Identification and characterization of putative human iodide transporter located at the apical membrane of thyrocytes. J Clin Endocrinol Metab. 2002;87:3500–3503
- SLC5A8, a sodium transporter, is tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A. 2003;100:8412–8417
- The human tumor suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol. 2004;557:719–731
- Expression in kidney and its role in Na(+)-coupled transport of lactate. J Biol Chem. 2004;279:44522–44532
- Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. Proc Natl Acad Sci U S A. 2006;103:7270–7275
- Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. Biochem J. 2009;417:379–389
- Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. J Gastrointest Surg. 2008;12:1773–1781
- SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sci. 2006;78:2419–2425
- CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implication. Int J Oncol. 2002;21:769–774
- A chromatin immunoprecipitation screen reveals protein kinase Cβ as a direct runx1 target gene. J Biol Chem. 2004;279:825–830
- Identification of novel binding elements and gene targets for the homeodomain protein BARX2. J Biol Chem. 2004;279:14520–14530
- . Cloning and characterization of the thyroid iodide transporter. Nature. 1996;379:458–460
- Hepatocyte nuclear factor-1 α, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription, implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem. 2002;277:31909–31917
- A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP. Mol Cell Biol. 2002;22:5467–5478
- CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology. 2002;123:1565–1577
- A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol. 1994;14:7340–7351
- Isolation and characterization of target sequences of the chicken CdxA homeobox gene. Nucleic Acids Res. 1993;21:4915–4922
- Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene. 2008;27:4497–4502
- Expression and localization of insulin receptor substrate 2 in normal intestine and colorectal tumors (Regulation by intestine-specific transcription factor CDX2). Gut. 2009;58:1250–1259
- Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. Proc Natl Acad Sci U S A. 2009;106:1936–1941
- Colon carbonic anhydrase 1: transactivation of gene expression by the homeodomain protein Cdx2. FEBS Lett. 1998;423:218–222
- The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. Gastroenterology. 2000;118:115–127
- Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem. 2003;278:51549–51556
- CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. Gastroenterology. 2005;128:946–961
- Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2001;280:G149–G156
- Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene. 2001;20:4884–4890
- Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1 α. J Biol Chem. 2002;277:21361–21370
- CDX2, a homeobox transcription factor, up-regulates transcription of the p21/WAF/CIP1 gene. Oncogene. 2003;22:7942–7949
- Colonic health: fermentation and short chain fatty acids. J Clin Gasteroenterol. 2006;40:235–243
- . Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006;6:38–51
- Modulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats. Oncol Rep. 2008;20:793–801
- Suppression of intestinal polyp development by low-fat and high-fiber diet in Apc(Δ716) knockout mice. Carcinogenesis. 1997;18:1863–1865
- Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem. 2008;283:24729–24737
Conflicts of interest The authors disclose no conflicts.
Funding Supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to M.M.T.).
PII: S0016-5085(09)01944-1
doi: 10.1053/j.gastro.2009.10.047
© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 138, Issue 2
, Pages 627-635
, February 2010

