Gastroenterology
Volume 138, Issue 3 , Pages 1189-1199.e2 , March 2010

NFAT-Induced Histone Acetylation Relay Switch Promotes c-Myc-Dependent Growth in Pancreatic Cancer Cells

  • Alexander Köenig

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Thomas Linhart

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Katrin Schlengemann

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Kristina Reutlinger

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Jessica Wegele

      Affiliations

    • Department of Gastroenterology, University of Ulm, Ulm, Germany
    • ,
  • Guido Adler

      Affiliations

    • Department of Gastroenterology, University of Ulm, Ulm, Germany
    • ,
  • Garima Singh

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Leonie Hofmann

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Steffen Kunsch

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Thomas Büch

      Affiliations

    • Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilian University, Munich, Germany
    • ,
  • Eva Schäfer

      Affiliations

    • Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilian University, Munich, Germany
    • ,
  • Thomas M. Gress

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • ,
  • Martin E. Fernandez–Zapico

      Affiliations

    • Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota
    • ,
  • Volker Ellenrieder

      Affiliations

    • Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Marburg, Germany
    • Corresponding Author InformationReprint requests Address requests for reprints to: Volker Ellenrieder, MD, Department of Gastroenterology and Endocrinology, Philipps-University of Marburg, Baldingerstrasse, 35043 Marburg, Germany

Received 28 June 2009 ,Accepted 29 October 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the Deutsche Forschungsgemeinschaft (DFG, SFB-TR17; to V.E., A.G., and J.M.) and the Max Eder program of the German Cancer Research Foundation (Deutsche Krebshilfe, 70-3022-El I; to V.E.) and by the Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Division of Oncology Research, Mayo Clinic Cancer Center, Mayo Clinic Pancreatic SPORE P50 CA102701 and CA136526 (to M.E.F.-Z.).

PII: S0016-5085(09)01942-8

doi: 10.1053/j.gastro.2009.10.045

Gastroenterology
Volume 138, Issue 3 , Pages 1189-1199.e2 , March 2010

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