Gastroenterology
Volume 138, Issue 2 , Pages 583-594, February 2010

Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice

  • Edwin F. de Zoeten

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Liqing Wang

      Affiliations

    • Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Hong Sai

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Wolfgang H. Dillmann

      Affiliations

    • Division of Endocrinology/Metabolism, University of California, San Diego, La Jolla, California
    • ,
  • Wayne W. Hancock

      Affiliations

    • Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests Address requests for reprints to: Wayne W. Hancock, Division of Transplantation Immunology, Pathology and Laboratory Medicine, 916B Abramson Research Center, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104-4318. fax: (215) 590-7384

Received 23 February 2009; accepted 20 October 2009. published online 30 October 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the National Institutes of Health grants K08DK080189 (to E.F.d.Z.), R01AI073938 and P01AI073489 (to W.W.H.), and CDNHNF/NASPGHAN Fellow to Faculty Grant (to E.F.d.Z.).

PII: S0016-5085(09)01934-9

doi:10.1053/j.gastro.2009.10.037

Gastroenterology
Volume 138, Issue 2 , Pages 583-594, February 2010

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