Gastroenterology
Volume 138, Issue 2 , Pages 493-502 , February 2010

Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma

  • Anna S. Lok

      Affiliations

    • Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Anna S. Lok, MD, Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109. fax: 734-936-7024
    • ,
  • Richard K. Sterling

      Affiliations

    • Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia
    • ,
  • James E. Everhart

      Affiliations

    • Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    • ,
  • Elizabeth C. Wright

      Affiliations

    • Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    • ,
  • John C. Hoefs

      Affiliations

    • Division of Gastroenterology, University of California-Irvine, Irvine, California
    • ,
  • Adrian M. Di Bisceglie

      Affiliations

    • Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri
    • ,
  • Timothy R. Morgan

      Affiliations

    • Division of Gastroenterology, University of California-Irvine, Irvine, California
    • Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, California
    • ,
  • Hae–Young Kim

      Affiliations

    • New England Research Institutes, Watertown, Massachusetts
    • ,
  • William M. Lee

      Affiliations

    • Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas
    • ,
  • Herbert L. Bonkovsky

      Affiliations

    • Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut
    • Department of Molecular and Structural Biology and The Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, Connecticut
    • ,
  • Jules L. Dienstag

      Affiliations

    • Gastrointestinal Unit (Medical Services), Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • HALT-C Trial Group

Received 23 July 2009 ,Accepted 13 October 2009.

  • Image Result

    Box plot of AFP values in HCC cases and matched controls.

    Box plot of AFP values in HCC cases and matched controls.

  • Image Result

    Box plot of DCP values in HCC cases and matched controls.

    Box plot of DCP values in HCC cases and matched controls.

  • Image Result

    ROC curves of AFP alone, DCP alone, and combination of both markers (either marker increase) in differentiating HCC cases from controls at the time of HCC diagnosis.

    ROC curves of AFP alone, DCP alone, and combination of both markers (either marker increase) in differentiating HCC cases from controls at the time of HCC diagnosis.

 Conflicts of interest The authors disclose the following:Financial relationships of the authors with Hoffmann-La Roche, Inc., are as follows: A.S. Lok is a consultant; R.K. Sterling is a consultant, receives research support, and is on the speaker's bureau; J.C. Hoefs is on the speaker's bureau; T.R. Morgan is a consultant, on the speaker's bureau, and receives research support; A.M. Di Bisceglie is a consultant, on the speaker's bureau, and receives research support; W.M. Lee receives research support; and H.L. Bonkovsky receives research support. Financial relationships of the authors with Eisai Co, Ltd, are as follows: A.S. Lok receives research support. The remaining authors disclose no conflicts.

 Funding Supported by the National Institute of Diabetes & Digestive & Kidney Diseases (contract numbers are listed below); the National Institute of Allergy and Infectious Diseases (NIAID); the National Cancer Institute; the National Center for Minority Health and Health Disparities; by General Clinical Research Center and Clinical and Translational Science Center grants from the National Center for Research Resources and National Institutes of Health (grant numbers are listed below); by Eisai Co, Ltd, through a Materials Cooperative Research and Development Agreement (M-CRADA) with the National Institutes of Health for testing of des-γ-carboxy prothrombin; and by Hoffmann–La Roche, Inc, through a Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health.

 View this article's video abstract at www.gastrojournal.org

PII: S0016-5085(09)01857-5

doi: 10.1053/j.gastro.2009.10.031

Gastroenterology
Volume 138, Issue 2 , Pages 493-502 , February 2010

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