Gastroenterology
Volume 138, Issue 2 , Pages 705-714.e4, February 2010

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

  • Jelena Mann

      Affiliations

    • Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    • Corresponding Author InformationReprint requests Address requests for reprints to: Jelena Mann, Institute of Cellular Medicine, Faculty of Medical Sciences, 4th Floor, Cookson Building, Newcastle University, Framlington Place, Newcastle upon Tyne, NE24HH, United Kingdom. fax: (44) 191 222 5455
    • ,
  • David C.K. Chu

      Affiliations

    • The University of Georgia College of Pharmacy, Athens, GA
    • ,
  • Aidan Maxwell

      Affiliations

    • Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    • ,
  • Fiona Oakley

      Affiliations

    • Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    • ,
  • Nian–Ling Zhu

      Affiliations

    • Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA
    • Greater Los Angeles Healthcare System, Los Angeles, CA
    • ,
  • Hidekazu Tsukamoto

      Affiliations

    • Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA
    • Greater Los Angeles Healthcare System, Los Angeles, CA
    • ,
  • Derek A. Mann

      Affiliations

    • Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

Received 16 June 2009; accepted 7 October 2009. published online 19 October 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the National Institutes of Health National Institute on Alcohol Abuse and Alcoholism (grants R21AA016682, R24AA012885, and P50AA11999 to H.T. and D.A.M.); the Medical Research Service of Veterans Affairs; grants from the Medical Research Council, Wellcome Trust, and British Liver Trust (to D.A.M. and J.M.); and the Newcastle Health Care Charity and Newcastle upon Tyne Hospitals NHS Charity (to J.M.).

PII: S0016-5085(09)01774-0

doi:10.1053/j.gastro.2009.10.002

Gastroenterology
Volume 138, Issue 2 , Pages 705-714.e4, February 2010

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