Gastroenterology
Volume 138, Issue 3 , Pages 1143-1154.e2, March 2010

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

  • Martin Schneider

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    • ,
  • Katie Van Geyte

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • ,
  • Peter Fraisl

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • ,
  • Judit Kiss

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    • ,
  • Julián Aragonés

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • Immunology Department, Hospital de la Princess-UAM, Madrid, Spain
    • ,
  • Massimiliano Mazzone

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • ,
  • Heimo Mairbäurl

      Affiliations

    • Medical Clinic VII, Sports Medicine, University of Heidelberg, Germany
    • ,
  • Katrien De Bock

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • ,
  • Nam Ho Jeoung

      Affiliations

    • Department of Biochemistry and Molecular Biology, Indiana School of Medicine, Indianapolis, Indiana
    • ,
  • Martin Mollenhauer

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    • ,
  • Maria Georgiadou

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • ,
  • Tammie Bishop

      Affiliations

    • Henry Wellcome Building of Molecular Physiology, Oxford, UK
    • ,
  • Carmen Roncal

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • ,
  • Andrew Sutherland

      Affiliations

    • Henry Wellcome Building of Molecular Physiology, Oxford, UK
    • ,
  • Benedicte Jordan

      Affiliations

    • Biomedical MRI Unit, U.C. Louvain, Louvain, Belgium
    • ,
  • Bernard Gallez

      Affiliations

    • Biomedical MRI Unit, U.C. Louvain, Louvain, Belgium
    • ,
  • Jürgen Weitz

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    • ,
  • Robert A. Harris

      Affiliations

    • Department of Biochemistry and Molecular Biology, Indiana School of Medicine, Indianapolis, Indiana
    • ,
  • Patrick Maxwell

      Affiliations

    • Imperial College London, London, UK
    • ,
  • Myriam Baes

      Affiliations

    • Laboratory of Cell Metabolism, K.U. Leuven, Leuven, Belgium
    • ,
  • Peter Ratcliffe

      Affiliations

    • Henry Wellcome Building of Molecular Physiology, Oxford, UK
    • ,
  • Peter Carmeliet

      Affiliations

    • Vesalius Research Center, K.U. Leuven, Leuven, Belgium
    • Vesalius Research Center, VIB, Leuven, Belgium
    • Corresponding Author InformationReprint requests Address requests for reprints to: P. Carmeliet, MD, PhD, Vesalius Research Center (VRC), VIB, K. U. Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium. fax: (32) 16 34 59 90

Received 2 May 2009; accepted 25 September 2009. published online 09 October 2009.

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 Conflicts of interest The authors disclose the following: P.R. and P.M. are scientific co-founders of ReOx Ltd, a University spin-out company that seeks to develop HIF Hydroxylase Inhibitors. The remaining authors disclose no conflicts.

 Funding Supported by the Emmy Noether-Program of the Deutsche Forschungsgemeinschaft (to MS), by grant IUAP06/30 from the Federal Government Belgium, and by grants FWO G.0265 and FWO G.0387 from the Flanders Research Foundation, Belgium.

PII: S0016-5085(09)01752-1

doi:10.1053/j.gastro.2009.09.057

Gastroenterology
Volume 138, Issue 3 , Pages 1143-1154.e2, March 2010

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