Gastroenterology
Volume 138, Issue 2 , Pages 649-658, February 2010

Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2

  • Songbai Lin

      Affiliations

    • Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Sunil Yeruva

      Affiliations

    • Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    • ,
  • Peijian He

      Affiliations

    • Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Anurag Kumar Singh

      Affiliations

    • Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    • ,
  • Huanchun Zhang

      Affiliations

    • Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Mingmin Chen

      Affiliations

    • Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    • ,
  • Georg Lamprecht

      Affiliations

    • Department of Medicine, University of Tübingen, Tübingen, Germany
    • ,
  • Hugo R. de Jonge

      Affiliations

    • Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands
    • ,
  • Ming Tse

      Affiliations

    • Departments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Mark Donowitz

      Affiliations

    • Departments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Boris M. Hogema

      Affiliations

    • Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands
    • ,
  • Jerold Chun

      Affiliations

    • Department of Molecular Biology, Scripps Research Institute, La Jolla, California
    • ,
  • Ursula Seidler

      Affiliations

    • Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    • ,
  • C. Chris Yun

      Affiliations

    • Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    • Department of Physiology, Emory University School of Medicine, Atlanta, Georgia
    • Corresponding Author InformationReprint requests Address requests for reprints to: C. Chris Yun, PhD, Division of Digestive Diseases, Emory University School of Medicine, Whitehead Building, Room 201, 615 Michael Street, Atlanta, Georgia 30322

Received 9 July 2009; accepted 23 September 2009. published online 05 October 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding This work was funded by National Institutes of Health grants DK061416 (CCY), MH51699 and HD50685 (JC) and by DFG SFB621-C9 (US). SL was supported by the Crohn's and Colitis Foundation of America. PH was supported by the American Heart Association. AS and MC were supported by postdoctoral stipends of the Hannover biomedical Research School that were funded by the DAAD and Abbot GmbH via the “matching fund” program. We thank the Emory Digestive Disease Research Development Center (supported by DK064399) for the use of light microscope and the Zeiss 510 confocal microscope and the Volkswagen Stiftung for funding of the Leica LSM.

PII: S0016-5085(09)01750-8

doi:10.1053/j.gastro.2009.09.055

Gastroenterology
Volume 138, Issue 2 , Pages 649-658, February 2010

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