Gastroenterology
Volume 138, Issue 1 , Pages 159-164 , January 2010

MELD Score Is an Important Predictor of Pretransplantation Mortality in HIV-Infected Liver Transplant Candidates

  • Aruna Subramanian

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationReprint requests Address requests for reprints to: Aruna Subramanian, MD, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 450D, Baltimore, Maryland 21287. fax: (410) 614-8488
    • ,
  • Mark Sulkowski

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Burc Barin

      Affiliations

    • Emmes Corporation, Rockville, Maryland
    • ,
  • Donald Stablein

      Affiliations

    • Emmes Corporation, Rockville, Maryland
    • ,
  • Michael Curry

      Affiliations

    • Beth Israel Deaconess Hospital, Boston, Massachusetts
    • ,
  • Nicholas Nissen

      Affiliations

    • Cedars-Sinai Medical Center, Los Angeles, California
    • ,
  • Lorna Dove

      Affiliations

    • Columbia University Medical Center, New York, New York
    • ,
  • Michelle Roland

      Affiliations

    • California Department of Public Health, Sacramento, California
    • ,
  • Sander Florman

      Affiliations

    • Tulane Medical Center, New Orleans, Louisiana
    • ,
  • Emily Blumberg

      Affiliations

    • University of Pennsylvania, Philadelphia, Pennsylania
    • ,
  • Valentina Stosor

      Affiliations

    • Northwestern University, Chicago, Illinois
    • ,
  • D.T. Jayaweera

      Affiliations

    • University of Miami, Miami, Florida
    • ,
  • Shirish Huprikar

      Affiliations

    • Mt. Sinai Hospital, New York, New York
    • ,
  • John Fung

      Affiliations

    • Cleveland Clinic Hospital, Cleveland, Ohio
    • ,
  • Timothy Pruett

      Affiliations

    • University of Virginia, Charlottesville, Virginia
    • ,
  • Peter Stock

      Affiliations

    • University of California, San Francisco, California
    • ,
  • Margaret Ragni

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania

Received 17 April 2009 ,Accepted 23 September 2009.

References 

  1. Mocroft A, Soriano V, Rockstroh J, et al. Is there evidence for an increase in the death rate from liver-related disease in patients with HIV?. AIDS. 2005;19:2117–2125
  2. Weber R, Sabin CA, Friis-Møller N, et al. Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med. 2006;166:1632–1641
  3. Koziel MJ, Peters MG. Viral hepatitis and HIV infection. N Engl J Med. 2007;356:1445–1454
  4. Sulkowski MS, Thomas DL, Chaisson RE, et al. Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA. 2000;283:74–80
  5. Sulkowski MS. Viral hepatitis and HIV coinfection. J Hepatol. 2008;48:353–367
  6. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33:464–470
  7. Kamath PS, Kim WR. The Model for End-Stage Liver Disease (MELD). Hepatology. 2007;45:797–805
  8. Ragni MV, Eghtesad B, Schlesinger KW, et al. Pre-transplant survival is shorter in HIV-positive than HIV-negative subjects with end-stage liver disease. Liver Transpl. 2005;11:1425–1430
  9. Pineda JA, Romero-Gómez M, Díaz-García F, et al. HIV co-infection shortens the survival of patients with hepatitis C virus-related decompensated cirrhosis. Hepatology. 2005;41:779–789
  10. Stock PG. Rapid deterioration of HIV co-infected patients waiting for liver transplantation is not predicted by MELD. Liver Transpl. 2005;11:1315–1317
  11. Pineda JA, Garcia-Garcia JA, Aguilar-Guisado M, et al. Clinical progression of hepatitis C virus-related chronic liver disease in human immunodeficiency virus-infected patients undergoing highly active antiretroviral therapy. Hepatology. 2007;46:622–630
  12. Ragni MV, Belle SH, Im K, et al. Survival in HIV-infected liver transplant recipients. J Infect Dis. 2003;188:1412–1420
  13. Fung JJ, Eghtesad B, Patel TK, et al. Liver transplantation in patients with HIV infection. Liver Transplantation. 2004;10(Suppl 2):S39–S53
  14. Soriano V, Puoti M, Sulkowski M, et al. Care of patients co-infected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel. AIDS. 2007;21:1073–1089
  15. Deuffic-Burban S, Poynard T, Sulkowski MS, et al. Estimating the future health burden of chronic hepatitis C and human immunodeficiency virus infections in the United States. J Viral Hepatol. 2007;14:107–115
  16. Ragni MV, Belle SH. Impact of human immunodeficiency virus (HIV) on progression to end-stage liver disease in individuals with hemophilia and hepatitis C. J Infect Dis. 2001;183:1112–1115
  17. Ragni MV, Schillo R, Nalesnik MA, et al. HAART improves ESLD-free survival in HIV-HCV co-infection. Haemophilia. 2009;15:552–558
  18. Bräu N, Fox RK, Xiao P, et al. Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a US-Canadian multicenter study. J Hepatol. 2007;47:527–537
  19. Biggins SW, Kim RW, Terrault NA, et al. Evidence-based Incorporation of serum sodium concentration into MELD. Gastroenterology. 2006;130:1652–1660

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by NIAID Grant U01 A1052748 (to P.S.) and R01 DA016065 (to M.S.S.). On behalf of Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR) Investigators.

PII: S0016-5085(09)01748-X

doi: 10.1053/j.gastro.2009.09.053

Gastroenterology
Volume 138, Issue 1 , Pages 159-164 , January 2010

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