Gastroenterology
Volume 138, Issue 2 , Pages 682-693.e4, February 2010

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

  • Paola Fisicaro

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Caterina Valdatta

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Marco Massari

      Affiliations

    • Unit of Infectious Diseases, Azienda Ospedaliera S.M.N. di Reggio Emilia; Reggio Emilia, Italy
    • ,
  • Elisabetta Loggi

      Affiliations

    • Department of Clinical Medicine, Laboratory of Cellular Immunology, University of Bologna, Bologna, Italy
    • ,
  • Elisabetta Biasini

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Luca Sacchelli

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Maria Cristina Cavallo

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Enrico M. Silini

      Affiliations

    • Anatomia e Istologia Patologica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Pietro Andreone

      Affiliations

    • Department of Clinical Medicine, Laboratory of Cellular Immunology, University of Bologna, Bologna, Italy
    • ,
  • Gabriele Missale

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • ,
  • Carlo Ferrari

      Affiliations

    • Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
    • Corresponding Author InformationReprint requests Address requests for reprints to: Carlo Ferrari, MD, Professor, Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci, 14, 43100 Parma, Italy. fax: (39) 0521-703 857

Received 6 March 2009; accepted 17 September 2009. published online 05 October 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the VIRGIL EC grant QLK2-CT-2002-00700; by Fondazione Cassa Risparmio di Parma, Parma, Italy; by grant 85/2007, Ricerca Finalizzata, Progetto Ordinario, Ministry of Health, Italy; and by Fondo per gli Investimenti della Ricerca di Base (grant No. RBNE013PMJ); and by the Ministry of Instruction, University and Research, Italy.

PII: S0016-5085(09)01747-8

doi:10.1053/j.gastro.2009.09.052

Gastroenterology
Volume 138, Issue 2 , Pages 682-693.e4, February 2010

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