Gastroenterology
Volume 138, Issue 1 , Pages 266-274, January 2010

The β3-Adrenoceptor Agonist GW427353 (Solabegron) Decreases Excitability of Human Enteric Neurons via Release of Somatostatin

  • Michael Schemann

      Affiliations

    • Human Biology, Technische Universität München, Freising, Germany
    • Corresponding Author InformationReprint requests Address requests for reprints to: Prof. Michael Schemann, Human Biology, Technische Universität München, Liesel-Beckmann-Strasse, D-85350 Freising-Weihenstephan, Germany. fax: (49) 8161 71 5785
    • ,
  • Nadia Hafsi

      Affiliations

    • Human Biology, Technische Universität München, Freising, Germany
    • ,
  • Klaus Michel

      Affiliations

    • Human Biology, Technische Universität München, Freising, Germany
    • ,
  • Olivia I. Kober

      Affiliations

    • Immuno Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline, Middlesex, United Kingdom
    • Faculty of Medical and Veterinary Sciences, Cellular and Molecular Medicine Department, University of Bristol, Bristol, United Kingdom
    • ,
  • Jutta Wollmann

      Affiliations

    • Human Biology, Technische Universität München, Freising, Germany
    • ,
  • Qin Li

      Affiliations

    • Human Biology, Technische Universität München, Freising, Germany
    • ,
  • Florian Zeller

      Affiliations

    • Surgery, Clinic Freising, Freising, Germany
    • ,
  • Rupert Langer

      Affiliations

    • Department of Pathology, Technische Universität München, München, Germany
    • ,
  • Kevin Lee

      Affiliations

    • Immuno Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline, Middlesex, United Kingdom
    • ,
  • Selim Cellek

      Affiliations

    • Immuno Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline, Middlesex, United Kingdom

Received 12 January 2009; accepted 17 September 2009. published online 27 September 2009.

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 Conflicts of interest K.L. is an employee of GlaxoSmithKline, UK. S.C. and O.I.K. were employees of GSK at the time of the experiments. The remaining authors have no conflicts to disclose.

 Funding This study has been in part supported by a research grant from GlaxoSmithKline.

PII: S0016-5085(09)01696-5

doi:10.1053/j.gastro.2009.09.046

Gastroenterology
Volume 138, Issue 1 , Pages 266-274, January 2010

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