Gastroenterology
Volume 137, Issue 5 , Pages 1577-1579 , November 2009

A Novel Role for the Fibroblast Growth Factor 21 in Acute Pancreatitis

  • Hana Algül

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Hana Algül, MD, MPH, II. Medizinische Klinik, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, D-81675 München, Germany

  • Image Result

    Schematic illustration of the effects of FGF21 during AP. Acinar cell damage results in FGF21 expression. Then, PDGF and subsequent activation of PSCs are inhibited. Furthermore, FGF21 can act as inhi

    Schematic illustration of the effects of FGF21 during AP. Acinar cell damage results in FGF21 expression. Then, PDGF and subsequent activation of PSCs are inhibited. Furthermore, FGF21 can act as inhibitor of the Egr-1 pathway by acting in a paracrine/autocrine fashion via the βKlotho receptor.

 Conflicts of interest The author discloses no conflicts.

PII: S0016-5085(09)01665-5

doi: 10.1053/j.gastro.2009.09.024

Gastroenterology
Volume 137, Issue 5 , Pages 1577-1579 , November 2009

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