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Gastroenterology
Volume 137, Issue 5
, Pages 1548-1556
, November 2009
Physiology, Injury, and Recovery of Interstitial Cells of Cajal: Basic and Clinical Science
References
- . Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine. J Physiol. 1998;513:203–213
- High-conductance chloride channels generate pacemaker currents in interstitial cells of Cajal. Gastroenterology. 2002;123:1627–1636
- Substance P activates a non-selective cation channel in murine pacemaker ICC. Neurogastroenterol Motil. 2009;21:985–e79
- Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1370–G1381
- Sodium current in human intestinal interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol. 2003;285:G1111–G1121
- Function of interstitial cells of Cajal in the rabbit portal vein. Circ Res. 2004;95:619–626
- Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers. J Physiol. 2006;576:695–705
- . About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract. J Cell Mol Med. 2005;9:468–473
- Comparison of mechanical and electrical activity and interstitial cells of Cajal in urinary bladders from wild-type and W/Wv mice. Br J Pharmacol. 2009;156:273–283
- . Gut peristalsis is governed by a multitude of cooperating mechanisms. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1–G8
- . Spatial and temporal coupling between slow waves and pendular contractions. Am J Physiol Gastrointest Liver Physiol. 2005;289:G898–G903
- . The movements and innervation of the small intestine. J Physiol. 1899;24:99–143
- . Architecture of enteric neural circuits involved in intestinal motility. Eur Rev Med Pharmacol Sci. 2008;12(Suppl 1):3–19
- Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine. Am J Physiol Gastrointest Liver Physiol. 2005;289:G539–G549
- . Propagation of slow waves in the guinea-pig gastric antrum. J Physiol. 2006;571:165–177
- Control of motility patterns in the human colonic circular muscle layer by pacemaker activity. J Physiol. 1998;510:309–320
- Synaptic specializations exist between enteric motor nerves and interstitial cells of Cajal in the murine stomach. J Comp Neurol. 2005;493:193–206
- Muscarinic regulation of pacemaker frequency in murine gastric interstitial cells of Cajal. J Physiol. 2003;546:415–425
- Ion channels in interstitial cells of Cajal as targets for neurotransmitter action. Neurogastroenterol Motil. 2004;16(suppl 1):106–111
- . Nitric oxide decreases the excitability of interstitial cells of Cajal through activation of the BK channel. J Cell Mol Med. 2008;12:1718–1727
- Ultrastructural evidence for communication between intramuscular vagal mechanoreceptors and interstitial cells of Cajal in the rat fundus. Neurogastroenterol Motil. 2008;20:69–79
- . Interstitial cells of Cajal in enteric neurotransmission. Gut. 2000;47(suppl 4):iv40–iv43
- Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci. 2000;20:1393–1403
- Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci U S A. 1996;93:12008–12013
- Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn. 2007;236:60–72
- Lower esophageal sphincter is achalasic in nNOS(−/−) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001;121:34–42
- Interstitial cells of Cajal and neuromuscular transmission in the rat lower oesophageal sphincter. Neurogastroenterol Motil. 2007;19:484–496
- Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation. Am J Physiol Gastrointest Liver Physiol. 2008;294:G589–G594
- Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex. Gut. 2005;54:1107–1113
- C-Kit mutant mice have a selective loss of vagal intramuscular mechanoreceptors in the forestomach. Anat Embryol (Berl). 2001;204:11–26
- Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy. Am J Gastroenterol. 2006;101:1299–1304
- Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy. Am J Physiol Gastrointest Liver Physiol. 2009;296:G211–G218
- A mutation in telethonin alters Nav1.5 function. J Biol Chem. 2008;283:16537–16544
- . Toward a concept of stretch-coupling in smooth muscle (I. Anatomy of intestinal segmentation and sleeve contractions). Anat Rec. 2001;262:110–124
- Loss of interstitial cells of Cajal and development of electrical dysfunction in murine small bowel obstruction. J Physiol. 2001;536:555–568
- Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system. Gastroenterology. 2001;120:561–567
- Identification of neurons that express stem cell factor in the mouse small intestine. Gastroenterology. 1998;115:898–908
- Regulation of interstitial cells of Cajal in the mouse gastric body by neuronal nitric oxide. Neurogastroenterol Motil. 2007;19:585–595
- Ultrastructural injury to interstitial cells of Cajal and communication with mast cells in Crohn's disease. Neurogastroenterol Motil. 2007;19:349–364
- Intramuscular interstitial cells of Cajal associated with mast cells survive nitrergic nerves in achalasia. Neurogastroenterol Motil. 2006;18:556–568
- Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Am J Physiol Gastrointest Liver Physiol. 2004;287:G638–G646
- Diagnostic challenges of motility disorders: optimal detection of CD117+ interstitial cells of Cajal. Histopathology. 2009;54:286–294
- . Interstitial cells of Cajal in health and disease. Neurogastroenterol Motil. 2008;20(suppl 1):54–63
- Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol. 2009;118:270–301
- Changes in interstitial cells of Cajal at the deep muscular plexus are associated with loss of distention-induced burst-type muscle activity in mice infected by Trichinella spiralis. Am J Pathol. 2005;167:437–453
- Intestinal surgical resection disrupts electrical rhythmicity, neural responses, and interstitial cell networks. Gastroenterology. 2004;127:1748–1759
- Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs. Virchows Arch. 2006;449:348–357
- An age-dependent proliferation is involved in the postnatal development of interstitial cells of Cajal in the small intestine of mice. Histochem Cell Biol. 2009;131:43–53
- Apoptotic cell death of human interstitial cells of Cajal. Neurogastroenterol Motil. 2009;21:85–93
- Blockade of kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype. Gastroenterology. 1999;117:140–148
- Plasticity of interstitial cells of Cajal: a study of mouse colon. Cell Tissue Res. 2006;325:211–217
- Progenitors of interstitial cells of Cajal in the postnatal murine stomach. Gastroenterology. 2008;134:1083–1093
- Requirement of c-kit for development of intestinal pacemaker system. Development. 1992;116:369–375
- Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology. 2007;133:897–906
- IL-9 enhances growth of ICC, maintains network structure and strengthens rhythmicity of contraction in culture. J Cell Mol Med. 2006;10:687–694
- Reduced stem cell factor links smooth myopathy and loss of interstitial cells of Cajal in murine diabetic gastroparesis. Gastroenterology. 2006;130:759–770
- Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. Gastroenterology. 2008;135:2055–2064
- Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine. Physiol Genomics. 2007;31:492–509
- A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors. Gastroenterology. 1998;115:1090–1095
- . Gastrointestinal stromal tumour. Lancet. 2007;369:1731–1741
- Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA. Gastroenterology. 2006;131:1907–1912
- Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity. Gastroenterology. 2006;131:1734–1742
- Igf1r+/CD34+ immature ICC are putative adult progenitor cells, identified ultrastructurally as fibroblast-like ICC in Ws/Ws rat colon. J Cell Mol Med. 2009;
- . c-Kit immunoreactive interstitial cells in the human gastrointestinal tract. J Auton Nerv Syst. 1999;75:38–50
- . An ultrastructural study of the interstitial cells of Cajal of the human stomach. J Submicrosc Cytol Pathol. 1989;21:439–460
- Loss of enteric motor neurotransmission in the gastric fundus of Sl/Sl(d) mice. J Physiol. 2002;543:871–887
- Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol. 1995;269:C1577–C1585
- . WZsGreen/+: a new green fluorescent protein knock-in mouse model for the study of KIT-expressing cells in gut and cerebellum. Physiol Genomics. 2005;22:412–421
- c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res. 1995;280:97–111
- Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice. J Gastroenterol Hepatol. 2008;23:660–667
- Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis. Diabetes. 2000;49:1731–1739
- Interstitial cells of Cajal and electrical activity in ganglionic and aganglionic colons of mice. Am J Physiol Gastrointest Liver Physiol. 2002;283:G445–G456
- Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves. Gastroenterology. 1999;117:584–594
- . Distribution and ultrastructure of interstitial cells of Cajal in the gastric antrum of wild-type and Ws/Ws rats. Anat Embryol (Berl). 2003;206:453–460
- Immunoelectron-microscopic study of Kit-expressing cells in the jejunum of wildtype and Ws/Ws rats. Cell Tissue Res. 2001;304:21–30
- Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1499–G1510
- Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus. Am J Physiol Gastrointest Liver Physiol. 2008;294:G315–G326
- Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol. 1994;480:91–97
- W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature. 1995;373:347–349
Conflict of interest The authors disclose no conflicts.
Funding Supported by grants from the Canadian Institutes for Health Research (MOP 12874), the Canadian Association of Gastroenterology, and the National Institutes of Health (DK 57061 and DK68055).
PII: S0016-5085(09)01664-3
doi: 10.1053/j.gastro.2009.09.023
© 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 137, Issue 5
, Pages 1548-1556
, November 2009

