« Previous
Next »
Gastroenterology
Volume 138, Issue 1
, Pages 305-314
, January 2010
Hepatitis C Virus Core Protein Subverts the Antiviral Activities of Human Kupffer Cells
References
- . Viral hepatitis. Curr Opin Infect Dis. 1999;12:481–490
- . Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol. 2006;1:23–61
- . Hepatitis C and innate immunity: recent advances. Clin Liver Dis. 2008;12:675–692
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology. 2004;127:1513–1524
- gC1q receptor ligation selectively downregulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway. J Immunol. 2005;175:4706–4714
- Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J Virol. 2006;80:9226–9235
- Hepatitis C virus core protein impairs in vitro priming of specific T-cell responses by dendritic cells and hepatocytes. J Hepatol. 2008;48:51–60
- The activation state of human intrahepatic lymphocytes. Clin Exp Immunol. 2007;149:186–193
- . The liver as a lymphoid organ. Annu Rev Immunol. 2009;27:147–163
- Liver histology in patients with HBsAg negative anti-HBc and anti-HCV positive chronic hepatitis. J Med Virol. 2005;75:222–226
- Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology. 2007;133:1627–1636
- TLR-dependent cross talk between human Kupffer cells and NK cells. J Exp Med. 2008;205:233–244
- Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol. 2007;81:2545–2553
- The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J Biol Chem. 2002;277:24315–24320
- The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007;8:239–245
- Up-regulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007;81:9249–9258
- Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner. J Immunol. 2008;181:4926–4935
- Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J Virol. 2005;79:9320–9324
- Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol. 2004;11:1060–1067
- . PI3K and negative regulation of TLR signaling. Trends Immunol. 2003;24:358–363
- Triggering the interferon response: the role of IRF-3 transcription factor. J Interferon Cytokine Res. 1999;19:1–13
- . Hepatitis C virus proteins. World J Gastroenterol. 2007;13:2406–2415
- Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest. 2000;106:1239–1249
- . Frequency of gC1qR(+)CD4(+) T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol. 2009;132:401–411
- Synergistic reversal of intrahepatic HCVspecific CD8 T-cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathol. 2009;5:e1000313
- Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology. 2008;134:1927–1937
- Interferon-sensitive response element (ISRE) is mainly responsible for IFN-α-induced up-regulation of programmed death-1 (PD-1) in macrophages. Biochim Biophys Acta. 2008;1779:811–819
- PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T-cell apoptosis. J Hepatol. 2006;45:520–528
- Interferon-α enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol. 2004;155:172–182
- Up-regulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. Aids. 2008;22:655–658
- . Poly(I-C)-induced toll-like receptor 3 (TLR3)-mediated activation of NF-κB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem. 2003;278:16713–16719
- Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at toll-IL-1 receptor domain-containing adapter inducing IFN-α. Proc Natl Acad Sci U S A. 2004;101:3533–3538
- Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol. 2009;183:491–498
- CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol. 2008;181:4918–4925
- Antiviral response by natural killer cells through TRAIL gene induction by IFN-α/β. Eur J Immunol. 2001;31:3138–3146
- . Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine Growth Factor Rev. 2005;16:1–14
- . Triggering the innate antiviral response through IRF-3 activation. J Biol Chem. 2007;282:15325–15329
- Expression of costimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology. Hepatology. 1998;27:1600–1606
- Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology. 2007;45:1422–1432
- Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells. Hepatology. 2008;48:48–58
- Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci. 2005;30:194–204
- TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat Med. 2007;13:1324–1332
Conflicts of interest The authors disclose no conflicts.
Funding Supported in part by the Transplant Miracles Foundation.
PII: S0016-5085(09)01648-5
doi: 10.1053/j.gastro.2009.09.009
© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 138, Issue 1
, Pages 305-314
, January 2010

