Chromium in Parenteral Nutrition: Too Little or Too Much?

A proposed model for the effect of Cr on insulin action. (1) The inactive form of the insulin receptor is converted to the active form by binding insulin. (2) Insulin receptor activation stimulates the movement of Cr into the cell. (3) Cr binds to a peptide known as Apo-LMWCr. (4) LMWCr binds to the insulin receptor and enhances its activity. (5) The ability of the LMWCr to activate the insulin receptor is dependent on its Cr content. Adapted from Vincent.¹⁹