Gastroenterology
Volume 137, Issue 4 , Pages 1211-1214 , October 2009

Unraveling Smooth Muscle Contraction: The TRP Link

  • Indu S. Ambudkar

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Indu S. Ambudkar, PhD, Building 10, Room 1N-113; NIH, Bethesda MD 20892. Phone: 301-496-5298, 301-496-1363

References 

  1. Tsvilovskyy VV, Zholos AV, Aberle T, et al. Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology. 2009;137:1415–1424
  2. Bolton TB, Prestwich SA, Zholos AV, et al. Excitation-contraction coupling in gastrointestinal and other smooth muscles. Annu Rev Physiol. 1999;61:85–115
  3. Unno T, Matsuyama H, Okamoto H, et al. Muscarinic cationic current in gastrointestinal smooth muscles: signal transduction and role in contraction. Auton Autacoid Pharmacol. 2006;26:203–217
  4. Inoue R, Isenberg G. Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am J Physiol. 1990;258:C1173–C1178
  5. Sanders KM. Invited review: mechanisms of calcium handling in smooth muscles. J Appl Physiol. 2001;91:1438–1449
  6. Beech DJ, Muraki K, Flemming R. Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol. 2004;559:685–706
  7. Zholos AV, Bolton TB. Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle. Br J Pharmacol. 1997;122:885–893
  8. Wegener JW, Schulla V, Koller A, et al. Control of intestinal motility by the Cav1.2 L-type calcium channel in mice. FASEB J. 2006;20:1260–1262
  9. Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem. 2007;76:387–417
  10. Inoue R, Okada T, Onoue H, et al. The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res. 2001;88:325–332
  11. Dietrich A, Mederos YS, Gollasch M, et al. Increased vascular smooth muscle contractility in TRPC6−/− mice. Mol Cell Biol. 2005;25:6980–6989
  12. Weissmann N, Dietrich A, Fuchs B, et al. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A. 2006;103:19093–19098
  13. Plant TD, Schaefer M. TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium. 2003;33:441–450
  14. Dietrich A, Kalwa H, Storch U, et al. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch. 2007;455:465–477
  15. Zholos AV, Zholos AA, Bolton TB. G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gating. J Gen Physiol. 2004;123:581–598
  16. Lee KP, Jun JY, Chang IY, et al. TRPC4 is an essential component of the nonselective cation channel activated by muscarinic stimulation in mouse visceral smooth muscle cells. Mol Cells. 2005;20:435–441
  17. Otsuguro K, Tang J, Tang Y, et al. Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2008;283:10026–10036
  18. Kohda M, Komori S, Unno T, et al. Carbachol-induced oscillations in membrane potential and [Ca2+]i in guinea-pig ileal smooth muscle cells. J Physiol. 1998;511:559–571
  19. Hofmann T, Obukhov AG, Schaefer M, et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999;397:259–263
  20. Freichel M, Suh SH, Pfeifer A, et al. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice. Nat Cell Biol. 2001;3:121–127

 Conflicts of interest The author discloses no conflicts.

PII: S0016-5085(09)01490-5

doi: 10.1053/j.gastro.2009.08.025

Gastroenterology
Volume 137, Issue 4 , Pages 1211-1214 , October 2009

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