Gastroenterology
Volume 137, Issue 5 , Pages 1716-1724.e2 , November 2009

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

  • Marie A. Hildebrandt

      Affiliations

    • Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Christian Hoffmann

      Affiliations

    • Division of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Scott A. Sherrill–Mix

      Affiliations

    • Division of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Sue A. Keilbaugh

      Affiliations

    • Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Micah Hamady

      Affiliations

    • Department of Computer Science, University of Colorado, Boulder, Colorado
    • ,
  • Ying–Yu Chen

      Affiliations

    • Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Rob Knight

      Affiliations

    • Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado
    • ,
  • Rexford S. Ahima

      Affiliations

    • Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Frederic Bushman

      Affiliations

    • Division of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests Address requests for reprints to: Gary D. Wu, MD, Division of Gastroenterology, University of Pennsylvania School of Medicine, Suite 600, Clinical Research Building, 415 Curie Blvd, Philadelphia, Pennsylvania 19104. fax: (215) 573-2024; or Frederic D. Bushman, PhD, Department of Microbiology, University of Pennsylvania School of Medicine, 425 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, Pennsylvania 19104-6076. fax: (215) 573-4856
    • ,
  • Gary D. Wu

      Affiliations

    • Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests Address requests for reprints to: Gary D. Wu, MD, Division of Gastroenterology, University of Pennsylvania School of Medicine, Suite 600, Clinical Research Building, 415 Curie Blvd, Philadelphia, Pennsylvania 19104. fax: (215) 573-2024; or Frederic D. Bushman, PhD, Department of Microbiology, University of Pennsylvania School of Medicine, 425 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, Pennsylvania 19104-6076. fax: (215) 573-4856

Received 27 March 2009 ,Accepted 6 August 2009.

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 F.B. and G.D.W. contributed equally to this study.

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by NIH grants AI39368 (to G.D.W.), DK062348 (to R.S.A.), and DK078669 and HG004872 (to R.K.); the Molecular Biology and Mouse Physiology Cores of NIH/NIDDK center grants DK50306 and DK019525, respectively; and in part by the Penn Genome Frontiers Institute, NIH instrument grant S10RR024525, and a grant with the Pennsylvania Department of Health (to F.D.B. and G.D.W.).

PII: S0016-5085(09)01457-7

doi: 10.1053/j.gastro.2009.08.042

Gastroenterology
Volume 137, Issue 5 , Pages 1716-1724.e2 , November 2009

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