Gastroenterology
Volume 137, Issue 5 , Pages 1768-1775 , November 2009

Functional Variants in ADH1B and ALDH2 Coupled With Alcohol and Smoking Synergistically Enhance Esophageal Cancer Risk

  • Ri Cui

      Affiliations

    • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Yoichiro Kamatani

      Affiliations

    • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Atsushi Takahashi

      Affiliations

    • Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Masayuki Usami

      Affiliations

    • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Naoya Hosono

      Affiliations

    • Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Takahisa Kawaguchi

      Affiliations

    • Laboratory for Medical Informatics, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Tatsuhiko Tsunoda

      Affiliations

    • Laboratory for Medical Informatics, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Naoyuki Kamatani

      Affiliations

    • Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Michiaki Kubo

      Affiliations

    • Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Yusuke Nakamura

      Affiliations

    • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • Laboratory for International Alliance, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
    • ,
  • Koichi Matsuda

      Affiliations

    • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Koichi Matsuda, MD, PhD, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. fax: (81) 3-5449-5123

Received 30 January 2009 ,Accepted 31 July 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding This study was conducted as a part of Biobank Japan, funded by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government.

PII: S0016-5085(09)01425-5

doi: 10.1053/j.gastro.2009.07.070

Gastroenterology
Volume 137, Issue 5 , Pages 1768-1775 , November 2009

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