Gastroenterology
Volume 137, Issue 5 , Pages 1609-1620.e3 , November 2009

A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers

  • Katsuhiko Nosho

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • ,
  • Shoko Kure

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • ,
  • Natsumi Irahara

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • ,
  • Kaori Shima

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • ,
  • Yoshifumi Baba

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • ,
  • Donna Spiegelman

      Affiliations

    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Jeffrey A. Meyerhardt

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • ,
  • Edward L. Giovannucci

      Affiliations

    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Charles S. Fuchs

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Shuji Ogino

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
    • Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests Address requests for reprints to: Shuji Ogino, MD, PhD, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Room JF-215C, Boston, Massachusetts 02115. fax: (617) 582-8558

Received 24 March 2009 ,Accepted 6 August 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the US National Institutes of Health (P01 CA87969 to S. Hankinson, P01 CA55075 to W. Willett, P50 CA127003 to C.S.F., K07 CA122826 to S.O.); the Bennett Family Fund; the Entertainment Industry Foundation National Colorectal Cancer Research Alliance; and a fellowship grant from the Japan Society for Promotion of Science (to K.N.).

 The content is solely the responsibility of the authors and does not necessarily represent the official views of NCI or NIH. Funding agencies did not have any role in the design of the study; the collection, analysis, or interpretation of the data; the decision to submit the manuscript for publication; or the writing of the manuscript.

PII: S0016-5085(09)01393-6

doi: 10.1053/j.gastro.2009.08.002

Gastroenterology
Volume 137, Issue 5 , Pages 1609-1620.e3 , November 2009

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