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Gastroenterology
Volume 137, Issue 5
, Pages 1746-1756.e1
, November 2009
An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice
References
- . The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002;20:495–549
- Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut. 1991;32:1071–1075
- . The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol. 2008;8:458–466
- XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134:743–756
- . The role of the intestinal microflora in experimental colitis. Am J Clin Nutr. 1977;30:1819–1825
- . Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134:577–594
- Bacterial flagellin is a dominant antigen in Crohn's disease. J Clin Invest. 2004;113:1296–1306
- Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 2002;123:689–699
- Alterations of IgM, IgG, and IgA synthesis and secretion by peripheral blood and intestinal mononuclear cells from patients with ulcerative colitis and Crohn's disease. Gastroenterology. 1981;81:844–852
- IBD serological panels: facts and perspectives. Inflamm Bowel Dis. 2007;13:1561–1566
- Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease. Int Immunol. 1996;8:1387–1394
- Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J Immunol. 1997;159:44–52
- Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology. 1989;97:1562–1584
- Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2005;288:G403–G406
- Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005;128:2020–2028
- . FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007;7:715–725
- Targeting the neonatal Fc receptor for antigen delivery using engineered Fc fragments. J Immunol. 2008;181:7550–7561
- . pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol. 1976;71:666–669
- Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest. 1999;104:903–911
- Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004;20:769–783
- . The protection receptor for IgG catabolism is the β 2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A. 1996;93:5512–5516
- The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol. 2003;170:3528–3533
- Neonatal FcR expression in bone marrow-derives cells functions to protect serum IgG from catabolism. J Immunol. 2007;179:4580–4588
- Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A. 2008;105:9337–9342
- Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut. 2002;50:507–512
- Role of δγT cells in the inflammatory response of experimental colitis mice. J Immunol. 2003;171:5507–5513
- . An Fc receptor structurally related to MHC class I antigens. Nature. 1989;337:184–187
- Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest. 2006;116:2142–2151
- MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol. 2001;166:3266–3276
- The MHC class II-associated invariant chain interacts with the neonatal Fcγ receptor and modulates its trafficking to endosomal/lysosomal compartments. J Immunol. 2008;181:2572–2585
- The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J Clin Invest. 2004;113:1328–1333
- Intravenous immunoglobulin (IVIG) treatment of experimental colitis induced by dextran sulfate sodium in rats. Clin Exp Immunol. 1997;108:340–345
- Intravenous immunoglobulin therapy for active, extensive, and medically refractory idiopathic ulcerative or Crohn's colitis. Am J Gastroenterol. 1992;87:91–100
- Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade. J Immunol. 2007;178:5390–5398
- Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat Biotechnol. 2005;23:1283–1288
- Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A. 2008;105:2337–2342
- Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A. 2005;102:13610–13615
- Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest. 2007;117:3909–3921
- Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4+-cell depleted, athymic and NK-cell depleted SCID mice. Inflamm Res. 1996;45:181–191
- Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology. 1997;92:69–74
Conflicts of interest The authors disclose no conflicts.
Funding Supported by NIH DK53056 and the Harvard Digestive Diseases Center (DK034854) (to R.S.B. and W.I.L.), by NIH DK44319 and DK51362 (to R.S.B.), and by Crohn's and Colitis Foundation of America (to W.I.L.).
PII: S0016-5085(09)01382-1
doi: 10.1053/j.gastro.2009.07.059
© 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 137, Issue 5
, Pages 1746-1756.e1
, November 2009

