Gastroenterology
Volume 137, Issue 5 , Pages 1776-1784 , November 2009

Gastroesophageal Reflux Might Cause Esophagitis Through a Cytokine-Mediated Mechanism Rather Than Caustic Acid Injury

  • Rhonda F. Souza

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
    • Corresponding Author InformationReprint requests Address requests for reprints to: Rhonda F. Souza, MD, Department of GI, MC# 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, Texas 75216. fax: (214) 857-0328
    • ,
  • Xiaofang Huo

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • ,
  • Vivek Mittal

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • ,
  • Christopher M. Schuler

      Affiliations

    • Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • Caris Diagnostics, Irving, Texas
    • ,
  • Susanne W. Carmack

      Affiliations

    • Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • Caris Diagnostics, Irving, Texas
    • ,
  • Hui Ying Zhang

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • ,
  • Xi Zhang

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • ,
  • Chunhua Yu

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • ,
  • Kathy Hormi–Carver

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • ,
  • Robert M. Genta

      Affiliations

    • Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas
    • Caris Diagnostics, Irving, Texas
    • ,
  • Stuart J. Spechler

      Affiliations

    • Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Irving, Texas

Received 12 February 2009 ,Accepted 22 July 2009.

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 To view this article’s video abstract, go to the AGA's YouTube Channel.

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the Office of Medical Research, Department of Veterans Affairs (R.F.S. and S.J.S.), and the National Institutes of Health (DK63621 to R.F.S. and CA134571 to R.F.S. and S.J.S.).

PII: S0016-5085(09)01378-X

doi: 10.1053/j.gastro.2009.07.055

Gastroenterology
Volume 137, Issue 5 , Pages 1776-1784 , November 2009

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