Gastroenterology
Volume 137, Issue 3 , Pages 779-782 , September 2009

Can Too Much Acid Sour Your Pancreas?

  • John A. Williams

      Affiliations

    • Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests Address requests for reprints to: John A. Williams, MD, PhD, Department of Molecular & Integrative Physiology, University of Michigan, 7708 MS II, Ann Arbor, Michigan 48109-5622
    • ,
  • Matthew J. DiMagno

      Affiliations

    • Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Matthew J. DiMagno, MD, Department of Internal Medicine, Division of Gastroenterology and Hepatology, 6510 MSRB 1, Ann Arbor, Michigan, 48109

References 

  1. Pandol SJ, Saluja AK, Imrie CW, et al. Acute pancreatitis: bench to the bedside. Gastroenterology. 2007;132:1127–1151
  2. DiMagno MJ, Wamsteker EJ, Debenedet AT. Advances in managing acute pancreatitis. F1000 Medicine Reports. 2009;
  3. Bhoomagoud M, Jung T, Atladottir J, et al. Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. Gastroenterology. 2009;137:1083–1092
  4. Boron WF. Regulation of intracellular pH. Adv Physiol Educ. 2004;28:160–179
  5. Preissler M, Williams JA. Pancreatic acinar cell function: measurement of intracellular ions and pH and their relation to secretion. J Physiol. 1981;321:437–448
  6. Dufresne M, Bastie MJ, Vaysse N, et al. The amiloride sensitive Na+/H+ antiport in guinea pig pancreatic acini (Characterization and stimulation by caerulein). FEBS Lett. 1985;187:126–130
  7. Hellmessen W, Christian AL, Fasold H, et al. Coupled Na+-H+ exchange in isolated acinar cells from rat exocrine pancreas. Am J Physiol. 1985;249:G125–G136
  8. Muallem S, Pandol SJ, Beeker TG. Modulation of agonist-activated calcium influx by extracellular pH in rat pancreatic acini. Am J Physiol. 1989;257:G917–G924
  9. Carter KJ, Rutledge PL, Steer ML, et al. Secretagogue-induced changes in intracellular pH and amylase release in mouse pancreatic acini. Am J Physiol. 1987;253:G690–G696
  10. Bastie MJ, Williams JA. Gastrointestinal peptides activate Na(+)-H+ exchanger in AR42J cells by increasing its affinity for intracellular H+. Am J Physiol. 1990;258:G958–G966
  11. Muallem S, Loessberg PA. Intracellular pH-regulatory mechanisms in pancreatic acinar cells (II. Regulation of H+ and HCO3- transporters by Ca2(+)-mobilizing agonists). J Biol Chem. 1990;265:12813–12819
  12. Orci L, Ravazzola M, Anderson RG. The condensing vacuole of exocrine cells is more acidic than the mature secretory vesicle. Nature. 1987;326:77–79
  13. Steigerwalt RW, Williams JA. Characterization of cholecystokinin receptors on rat pancreatic membranes. Endocrinology. 1981;109:1746–1753
  14. Tsunoda Y, Stuenkel EL, Williams JA. Characterization of sustained [Ca2+]i increase in pancreatic acinar cells and its relation to amylase secretion. Am J Physiol. 1990;259:G792–G801
  15. Kahler SG, Sherwood WG, Woolf D, et al. Pancreatitis in patients with organic acidemias. J Pediatr. 1994;124:239–243
  16. Badalov N, Baradarian R, Iswara K, et al. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol. 2007;5:648–661
  17. Bultron G, Seashore MR, Pashankar DS, et al. Recurrent acute pancreatitis associated with propionic acidemia. J Pediatr Gastroenterol Nutr. 2008;47:370–371
  18. Burlina AB, Dionisi-Vici C, Piovan S, et al. Acute pancreatitis in propionic acidaemia. J Inherit Metab Dis. 1995;18:169–172
  19. Schuster HP. Prognostic value of blood lactate in critically ill patients. Resuscitation. 1984;11:141–146
  20. Gardner TB, Vege SS, Pearson RK, et al. Fluid resuscitation in acute pancreatitis. Clin Gastroenterol Hepatol. 2008;6:1070–1076
  21. Niederau C, Crass RA, Silver G, et al. Therapeutic regimens in acute experimental hemorrhagic pancreatitis (Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor). Gastroenterology. 1988;95:1648–1657
  22. Forsythe SM, Schmidt GA. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000;117:260–267
  23. Moreno A, Quereda C, Moreno L, et al. High rate of didanosine-related mitochondrial toxicity in HIV/HCV-coinfected patients receiving ribavirin. Antivir Ther. 2004;9:133–138
  24. Brinkman K, ter Hofstede HJ, Burger DM, et al. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS. 1998;12:1735–1744
  25. Yeo TK, Kintner J, Armand R, et al. Sublethal concentrations of gemcitabine (2′,2′-difluorodeoxycytidine) alter mitochondrial ultrastructure and function without reducing mitochondrial DNA content in BxPC-3 human pancreatic carcinoma cells. Hum Exp Toxicol. 2007;26:911–921
  26. Nair S, Yadav D, Pitchumoni CS. Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA. Am J Gastroenterol. 2000;95:2795–2800

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)01196-2

doi: 10.1053/j.gastro.2009.07.036

Gastroenterology
Volume 137, Issue 3 , Pages 779-782 , September 2009

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