Intestinal Lipid Absorption, GLP-2, and CD36: Still More Mysteries to Moving Fat

GLP2 enhances intestinal lipid absorption, but how? GLP-2 (triangles) binds its receptor (GLP-2R) on intestinal L cells, generating mediators including IGF-1, which signals via IGF-1 receptors (IGF-1R) on epithelial cells. These various signals promote CD36 glycosylation, in turn altering epithelial long chain FA (LCFA) and monoacylglycerol (MAG) processing into TG via diacylglycerol acyltransferase 1 (Dgat1) and monoacylglycerol acyltransferase (Mgat). The rate-limiting step in CM formation is fusion of nascent apolipoprotein B48 (apoB48) with the luminal endoplasmic reticulum (ER) chaperone Mttp. GLP-2–mediated enhancement of intestinal lipid transport was attenuated in Cd36^–/– mice, but further work is required to define the mechanisms involved.