This Month in Gastroenterology

(A) Overall survival in endotherapy (blue line) and surgical (red line) groups (Kaplan–Meier curves; not significant). (B) Cancer-free survival in endotherapy (blue line) and surgical (red line) groups (Kaplan–Meier curves; P = .01).

Kaplan–Meier curves for each group (treatment by coma category) showing transplant-free survival to 365 days. Patients in the NAC I–II group demonstrated significantly greater transplant-free survival than the other 3 groups (largest P = .017).

Oral intake of S boulardii inhibits tumor growth in Apc^Min mice. After 9 weeks of oral administration of S boulardii, Apc^Min mice were humanely killed and the 10-cm section of the distal small intestine was harvested, from which was measured the number and size of intestinal tumors. Tumor number is significantly reduced in Apc^Min mice treated with S boulardii (n = 8) compared with control Apc^Min mice (n = 6; P = .03). Tumor size was also significantly reduced in the treated group (P = .03), as well as total tumor surface area (P = .02). Bars represent mean values ± standard error.

The effects of low extracellular pH (pHe) on cerulein-induced zymogen activation are reversible. Acini were exposed to different pHe conditions: group 1, pHe 7.4; group 2, pHe 7.0 for 30 minutes before cerulein hyperstimulation and maintained at pHe 7.0 for the remainder of the experiment; and group 3, pHe 7.0 for 15 minutes and then pHe was reversed to pH 7.4 and was allowed to equilibrate for another 15 minutes before treatment with or without cerulein (100 nmol/L) for 1 hour. Acini were collected and assayed for (A) trypsin and (B) chymotrypsin activity. Data are the mean values ± standard error of the mean of ≥4 individual experiments. *P < .05 compared with analogous treatment at pHe 7.4. ^#P < .05 compared with analogous treatment at pHe 7.0.