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Gastroenterology
Volume 137, Issue 4
, Pages 1238-1249
, October 2009
Biology and Treatment of Eosinophilic Esophagitis
References
- Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest. 1999;103:1719–1727
- . Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol. 2004;113:11–28
- Eosinophilic esophagitis is a component of the anticonvulsant hypersensitivity syndrome: description of two cases. Dig Liver Dis. 2008;40:145–148
- Audit of eosinophilic oesophagitis in children post-liver transplant. Pediatr Transplant. 2008 Nov 1;[Epub ahead of print]
- Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–1363
- . Eosinophilic esophagitis and gastritis in Rubinstein-Taybi syndrome. J Pediatr Gastroenterol Nutr. 2007;44:498–500
- Cow's milk protein-induced eosinophilic esophagitis in a child with gluten-sensitive enteropathy. J Pediatr Gastroenterol Nutr. 2007;44:386–388
- Eosinophilic oesophagitis and coeliac disease: is there an association?. Aliment Pharmacol Ther. 2007;26:487–493
- Eosinophilic oesophagitis and coeliac disease: is it just a casual association?. Gut. 2007;56:1029–1030
- . Eosinophilic esophagitis in children with celiac disease: new diagnostic and therapeutic dilemmas. J Gastroenterol Hepatol. 2008;23:993–994
- Eosinophilic esophagitis in children with celiac disease. J Gastroenterol Hepatol. 2008;23:1144–1148
- Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest. 2006;116:536–547
- A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity. 2004;21:367–377
- . Interleukin 15: its role in intestinal inflammation. Gut. 2006;55:444–445
- . How NKG2D ligands trigger autoimmunity?. Hum Immunol. 2006;67:204–207
- . Gluten: a two-edged sword (Immunopathogenesis of celiac disease). Springer Semin Immunopathol. 2005;27:217–232
- . Celiac disease—sandwiched between innate and adaptive immunity. Hum Immunol. 2006;67:460–468
- A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet. 2007;39:827–829
- Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet. 2008;40:395–402
- Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009;41:342–347
- The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol. 2000;95:1422–1430
- Allergic esophagitis in children: a clinicopathological entity. Am J Surg Pathol. 1999;23:390–396
- Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3:1198–1206
- . Eosinophilic esophagitis. N Engl J Med. 2004;351:940–941
- . Eosinophilic esophagitis. Curr Opin Pediatr. 2005;17:690–694
- Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005;61:795–801
- Eosinophilic oesophagitis in patients presenting with dysphagia—a prospective analysis. Aliment Pharmacol Ther. 2008;28:1140–1146
- Prevalence of esophageal dysmotility in a cohort of patients with esophageal biopsies consistent with eosinophilic esophagitis. Dis Esophagus. 2009;6:543–548
- Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic esophagitis. Gut. 2009;58:1056–1062
- Manometric findings in adult eosinophilic oesophagitis: a study of 12 cases. Eur J Gastroenterol Hepatol. 2007;19:417–424
- . Esophageal dysmotility in patients who have eosinophilic esophagitis. Gastrointest Endosc Clin North Am. 2008;18:73–89ix
- . Atopic characteristics of adult patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2008;6:531–535
- Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol. 2007;119:731–738
- Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. Gastroenterology. 2008;134:1316–1321
- 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr. 2009;48:30–36
- Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol. 2009;104:828–833
- Clinical and endoscopic features of eosinophilic esophagitis in adults. Gastrointest Endosc. 2003;58:516–522
- . Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia. Arch Dis Child. 2006;91:1000–1004
- . Eosinophilic infiltration of the esophagus: gastroesophageal reflux versus eosinophilic esophagitis in children—discussion on daily practice. J Pediatr Surg. 2004;39:e4–e7
- Esophageal eosinophilia with dysphagia (A distinct clinicopathologic syndrome). Dig Dis Sci. 1993;38:109–116
- Ringed oesophagus and idiopathic eosinophilic oesophagitis in adults: an association in two cases. Dig Liver Dis. 2005;37:129–134
- Eosinophilic esophagitis. Isr Med Assoc J. 2006;8:587
- Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2002;89:429–432
- Primary eosinophilic esophagitis. Dis Esophagus. 2003;16:165–168
- Eosinophilic esophagitis in adults, an emerging cause of dysphagia (Description of 9 cases). Rev Esp Enferm Dig. 2005;97:229–239
- Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion. 2004;70:109–116
- The first Asian case report of eosinophilic esophagitis in an asymptomatic adult: what about a proton pump inhibitor trial?. J Chin Med Assoc. 2009;72:166–167
- Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol. 1999;2:15–18
- . Eosinophilic esophagitis. Gastroenterol Clin North Am. 2003;32:949–966
- . Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002;56:260–270
- . Eosinophilic esophagitis: escalating epidemiology?. J Allergy Clin Immunol. 2005;115:418–419
- Prevalence of eosinophilia and eosinophilic esophagitis in adults in the community: a random population based study (Kalixanda) (abstr). Gastroenterology. 2006;130:A575
- Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol. 2009;7:420–426426 e1–2
- Research and clinical challenges in paediatric inflammatory bowel disease. Dig Liver Dis. 2008;40:32–38
- . Celiac disease. Curr Opin Gastroenterol. 2008;24:687–691
- . Eosinophilic esophagitis: a retrospective review of esophageal biopsy specimens from 1992 to 2004 at an adult academic medical center. Am J Clin Pathol. 2009;131:788–792
- Pathogenesis and clinical features of eosinophilic esophagitis. J Allergy Clin Immunol. 2001;108:891–894
- Histopathologic variability in children with eosinophilic esophagitis. Am J Gastroenterol. 2009;104:716–721
- . Histopathologic features of eosinophilic esophagitis. Gastrointest Endosc Clin North Am. 2008;18:59–71viii–ix
- Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2004;2:568–575
- . Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2006;42:506–509
- Is the etiology of eosinophilic esophagitis in adults a response to allergy or reflux injury? (Study of cellular proliferation markers). Dis Esophagus. 2009;22:249–255
- Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients. Mod Pathol. 2006;19:90–96
- Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002;122:1216–1225
- A randomized double-blind-placebo controlled trial of fluticasone proprionate for pediatric eosinophilic esophagitis. Gastroenterology. 2006;131:1381–1391
- Immunophenotypic characterization and quantification of the epithelial inflammatory infiltrate in eosinophilic esophagitis through stereology: an analysis of the cellular mechanisms of the disease and the immunologic capacity of the esophagus. Am J Surg Pathol. 2007;31:598–606
- A novel histological scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2009;7:749–755.e11
- High-resolution EUS in children with eosinophilic “allergic” esophagitis. Gastrointest Endosc. 2003;57:30–36
- . Correlation of endoscopy and histology in the gastroesophageal mucosa in children: are routine biopsies justified?. J Clin Gastroenterol. 2000;31:213–216
- Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–343
- . Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol. 2007;7:274–278
- Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4:1097–1102
- An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107:83–90
- Interleukin-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002;168:2464–2469
- . Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology. 2003;125:1419–1427
- Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354). Clin Exp Allergy. 2005;35:1096–1103
- Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology. 2005;129:985–994
- Eosinophil infiltration of the oesophageal mucosa in patients with pollen allergy during the season. Clin Exp Allergy. 2005;35:1423–1431
- IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol. 2007;120:204–214
- . Eosinophilic esophagitis: pathogenesis, genetics, and therapy. J Allergy Clin Immunol. 2006;118:1054–1059
- Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol. 2008;6:621–629
- Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. Hum Pathol. 2007;38:1744–1753
- Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 2008;1:289–296
- Filaggrin in atopic dermatitis. J Allergy Clin Immunol. 2008;122:689–693
- A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet. 2009;41:602–608
- Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol. 2008;128:2248–2258
- Local B cells and IgE production in the esophageal mucosa in eosinophilic esophagitis. Gut. 2009 Jun 14;[Epub ahead of print]
- Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2007;81:916–924
- Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008;134:204–214
- Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007;45:22–31
- Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis. Dig Dis Sci. 2006;51:1934–1941
- Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004;113:115–119
- Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol. 2006;118:1312–1319
- Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J Allergy Clin Immunol. 2008;121:1473–14831483 e1–4
- Mepolizumab, a humanized monoclonal antibody to IL-5, for severe eosinophilic esophagitis in adults: a randomized placebo-controlled double-blind trial. J Allergy Clin Immunol. 2008;121:S44
- Familial dysphagia and eosinophilia. Gastrointest Endosc. 2007;65:330–334
- . Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005;61:165–167
- . The genetic background of common diseases. Acta Genet Stat Med. 1953;257–265
- Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children. Am J Respir Crit Care Med. 2000;162:1587–1590
- Eosinophil infiltration and degranulation in esophageal mucosa from adult patients with eosinophilic esophagitis (EE) (A retrospective comparative pathologic biopsy study). J Clin Pathol. 2006;59:1175–1180
- The cytotoxic properties of the eosinophil major basic protein. J Immunol. 1979;123:2925
- . The eosinophil. Annu Rev Immunol. 2006;24:147–174
- Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein. J Immunol. 1986;137:2913–2917
- . Recombinant human eosinophil cationic protein: ribonuclease activity not essential for cytotoxicity. J Biol Chem. 1995;270:7876–7881
- Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med. 2008;205:79–90
- Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature. 1986;321:613–616
- . Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor. J Clin Invest. 1993;91:1314–1318
- FGF9-induced proliferative response to eosinophilic inflammation in oesophagitis. Gut. 2009;58:166–173
- Eosinophils: singularly destructive effector cells or purveyors of immunoregulation?. J Allergy Clin Immunol. 2007;119:1313–1320
- The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin. J Immunol. 2002;169:4604–4612
- . The role of eosinophils in pulmonary fibrosis. Int J Mol Med. 1998;1:43–53
- Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007;119:206–212
- Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med. 2008;14:949–953
- . Mitochondrial missile defense. Nat Med. 2008;14:910–912
- Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J Exp Med. 2008;205:699–710
- Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. J Exp Med. 2008;205:1285–1292
- Activated eosinophils in esophagitis in children: a transmission electron microscopic study. J Pediatr Gastroenterol Nutr. 1997;25:194–198
- A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol. 2001;2:353–360
- Intermittent dysphagia for solids associated with a multiringed esophagus: clinical features and response to dilatation. Dysphagia. 2007;22:55–62
- The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002;109:363–368
- Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis. J Allergy Clin Immunol. 2007;119:509–511
- . Detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seem. Ann Allergy Asthma Immunol. 2005;95:309–311
- Topical viscous budesonide suspension for treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2005;116:705–706
- Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children. Clin Gastroenterol Hepatol. 2008;6:165–173
- Eosinophilic oesophagitis: a novel treatment using montelukast. Gut. 2003;52:181–185
- Anti-TNF-alpha (infliximab) therapy for severe adult eosinophilic esophagitis. J Allergy Clin Immunol. 2008;122:425–427
- Corticosteroid-dependent eosinophilic oesophagitis: azathioprine and 6-mercaptopurine can induce and maintain long-term remission. Eur J Gastroenterol Hepatol. 2007;19:865–869
- . Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases. Clin Exp Allergy. 2008;38:1858–1865
- . Perspectives on the past decade of asthma genetics. J Allergy Clin Immunol. 2005;116:274–278
- . Gene-expression signatures in breast cancer. N Engl J Med. 2009;360:790–800
- . Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology. 2005;128:1089–1113
- . Clinical practice (Food allergy). N Engl J Med. 2008;359:1252–1260
- Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Proc Natl Acad Sci U S A. 2007;104:576–581
- . Oral tolerance, food allergy, and immunotherapy: implications for future treatment. J Allergy Clin Immunol. 2008;121:1344–1350
Conflicts of interest The author discloses the following: Dr Rothenberg is a paid consultant for Centocor, Ception Therapeutics, Merck & Co, Novartis, and Nycomed.
Funding Supported by National Institutes of Health grants R01 AI45898, R01 DK067255, U19 AI070235, R01 DK076893, R01 AI057803, and P30 DK078392; the Campaign Urging Research for Eosinophilic Disorders; the Food Allergy and Anaphylaxis Network; the Food Allergy Project; and the Buckeye Foundation.
PII: S0016-5085(09)01156-1
doi: 10.1053/j.gastro.2009.07.007
© 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 137, Issue 4
, Pages 1238-1249
, October 2009

