Gastroenterology
Volume 137, Issue 6 , Pages 2018-2029.e3 , December 2009

Immunoglobulin A: FcαRI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4

  • Lydia van der Steen

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Cornelis W. Tuk

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Jantine E. Bakema

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Gijs Kooij

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Arie Reijerkerk

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Gestur Vidarsson

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    • ,
  • Gerd Bouma

      Affiliations

    • Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Georg Kraal

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Helga E. de Vries

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Robert H.J. Beelen

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Marjolein van Egmond

      Affiliations

    • Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    • Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests Address requests for reprints to: Marjolein van Egmond, PhD, Department of Molecular Cell Biology and Immunology, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. fax: (31) 20-4448081

Received 6 April 2009 ,Accepted 18 June 2009.

References 

  1. Pamer EG. Immune responses to commensal and environmental microbes. Nat Immunol. 2007;8:1173–1178
  2. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427–434
  3. Elson CO, Cong Y, McCracken VJ, et al. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev. 2005;206:260–276
  4. van Egmond M, Damen CA, van Spriel AB, et al. IgA and the IgA Fc receptor. Trends Immunol. 2001;22:205–211
  5. van Egmond M, van Garderen E, van Spriel AB, et al. FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity. Nat Med. 2000;6:680–685
  6. Monteiro RC, van de Winkel JGJ. IgA Fc receptors. Annu Rev Immunol. 2003;21:177–204
  7. Woof JM, Mestecky J. Mucosal immunoglobulins. Immunol Rev. 2005;206:64–82
  8. Woof JM, Kerr MA. The function of immunoglobulin A in immunity. J Pathol. 2006;208:270–282
  9. Kerr MA. The structure and function of human IgA. Biochem J. 1990;271:285–296
  10. Brandtzaeg P. Role of secretory antibodies in the defence against infections. Int J Med Microbiol. 2003;293:3–15
  11. Otten MA, Rudolph E, Dechant M, et al. Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors. J Immunol. 2005;174:5472–5480
  12. van Egmond M, van Vuuren AJ, Morton HC, et al. Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18). Blood. 1999;93:4387–4394
  13. Frevert CW, Wong VA, Goodman RB, et al. Rapid fluorescence based measurement of PMN migration in vitro. J Immunol Methods. 1998;213:41–52
  14. Parent CA. Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr Opin Cell Biol. 2004;16:4–13
  15. Vidarsson G, van der Pol WL, van den Elsen JM, et al. Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B. J Immunol. 2001;166:6250–6256
  16. Andrews T, Sullivan KE. Infections in patients with inherited defects in phagocytic function. Clin Microbiol Rev. 2003;16:597–621
  17. Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006;6:173–182
  18. Nimmerjahn F, Ravetch JV. Fcgamma receptors: old friends and new family members. Immunity. 2006;24:19–28
  19. Van den Herik-Oudijk IE, Capel PJ, van der Bruggen T, et al. Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms. Blood. 1995;85:2202–2211
  20. Pfefferkorn LC, Yeaman GR. Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells (Aggregation induces the tyrosine phosphorylation of gamma 2). J Immunol. 1994;153:3228–3236
  21. Van den Herik-Oudijk IE, Ter Bekke MW, Tempelman MJ, et al. Functional differences between two Fc receptor ITAM signaling motifs. Blood. 1995;86:3302–3307
  22. Shen L, van Egmond M, Siemasko K, et al. Presentation of ovalbumin internalized via the immunoglobulin-A Fc receptor is enhanced through Fc receptor gamma-chain signaling. Blood. 2001;97:205–213
  23. Pasquier B, Launay P, Kanamaru Y, et al. Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity. 2005;22:31–42
  24. Kanamaru Y, Tamouza H, Pfirsch S, et al. IgA Fc receptor I signals apoptosis through the FcRgamma ITAM and affects tumor growth. Blood. 2007;109:203–211
  25. van Egmond M. FcαRI: a case of multiple personality disorder?. Blood. 2007;109:1–2
  26. Barrington R, Zhang M, Fischer M, et al. The role of complement in inflammation and adaptive immunity. Immunol Rev. 2001;180:5–15
  27. Roos A, Bouwman LH, van Gijlswijk-Janssen DJ, et al. Human IgA activates the complement system via the mannan-binding lectin pathway. J Immunol. 2001;167:2861–2868
  28. Herr AB, Ballister ER, Bjorkman PJ. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Nature. 2003;423:614–620
  29. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52:65–70
  30. Gulle H, Eibl MM, Wolf HM. Nitrocellulose particles adsorbed to immunoglobulins are a new and effective approach to induce cell activation dependant on receptor aggregation. J Immunol Methods. 1998;214:199–208

 Conflict of interest The authors disclose no conflicts.

 Funding This work was supported by the Netherlands Organization for Scientific Research (VIDI 016.086.320).

PII: S0016-5085(09)01019-1

doi: 10.1053/j.gastro.2009.06.047

Gastroenterology
Volume 137, Issue 6 , Pages 2018-2029.e3 , December 2009

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