Gastroenterology
Volume 137, Issue 4 , Pages 1415-1424 , October 2009

Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

  • Volodymyr V. Tsvilovskyy

      Affiliations

    • Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany
    • ,
  • Alexander V. Zholos

      Affiliations

    • Centre for Vision & Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queens's University Belfast, Belfast, United Kingdom
    • ,
  • Thomas Aberle

      Affiliations

    • Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany
    • ,
  • Stephan E. Philipp

      Affiliations

    • Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany
    • ,
  • Alexander Dietrich

      Affiliations

    • Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Universität Marburg, Marburg, Germany
    • ,
  • Michael X. Zhu

      Affiliations

    • Department of Neuroscience, Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio
    • ,
  • Lutz Birnbaumer

      Affiliations

    • Signal Transduction and Neurobiology Laboratories, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
    • ,
  • Marc Freichel

      Affiliations

    • Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany
    • Corresponding Author InformationReprint requests Address requests for reprints to: Marc Freichel, MD, Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Kirrberger Str. Gebäude 46 66421 Homburg, Germany. fax: (49) 6841-1626402
    • ,
  • Veit Flockerzi

      Affiliations

    • Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany

Received 23 November 2008 ,Accepted 18 June 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported in part by the Intramural Research Programs of the National Institutes of Health, National Institute of Environmental Health Sciences (Z01-ES-101684) to (L.B.), by National Institutes of Health grant DK081654 (M.X.Z. and A.V.Z.), by Homburger Forschungsförderung sprogramm (HOMFOR) (M.F., V.V.T., S.E.P., and V.F.), by Deutsche Forschungsgemeinschaft and Forschungskommission der UdS (M.F. and V.F.), and by Fonds der Chemischen Industrie (V.F.).

PII: S0016-5085(09)01018-X

doi: 10.1053/j.gastro.2009.06.046

Gastroenterology
Volume 137, Issue 4 , Pages 1415-1424 , October 2009

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