Gastroenterology
Volume 137, Issue 2 , Pages 425-427 , August 2009

In the Zone: How a Hepatocyte Knows Where It Is

  • Klaus H. Kaestner

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Klaus H. Kaestner, PhD, Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 7528 CRB415 Curle Boulevard, Philadelphia, Pennsylvania 19104. fax: 215-573-5892

References 

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  3. Gaasbeek Janzen JW, Gebhardt R, ten Voorde GH, et al. Heterogeneous distribution of glutamine synthetase during rat liver development. J Histochem Cytochem. 1987;35:49–54
  4. Kuo CF, Paulson KE, Darnell JE. Positional and developmental regulation of glutamine synthetase expression in mouse liver. Mol Cell Biol. 1988;8:4966–4971
  5. Christoffels VM, Grange T, Kaestner KH, et al. Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene. Mol Cell Biol. 1998;18:6305–6315
  6. Benhamouche S, Decaens T, Godard C, et al. Apc tumor suppressor gene is the “zonation-keeper” of mouse liver. Dev Cell. 2006;10:759–770
  7. Colletti M, Cicchini C, Conigliaro A, et al. Convergence of Wnt signaling on the HNF4α-driven transcription in controlling liver zonation. Gastroenterology. 2009;137:661–672
  8. Burke ZD, Reed KR, Phesse TJ, et al. Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology. 2009;137:2316–2324
  9. Parviz F, Matullo C, Garrison WD, et al. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet. 2003;34:292–296
  10. Sansom OJ, Meniel VS, Muncan V, et al. Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007;446:676–679
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 Conflicts of interest The author discloses no conflicts.

PII: S0016-5085(09)00989-5

doi: 10.1053/j.gastro.2009.06.020

Gastroenterology
Volume 137, Issue 2 , Pages 425-427 , August 2009

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