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Gastroenterology
Volume 137, Issue 3
, Pages 997-1005.e4
, September 2009
Glucagon-Like Peptide-2 Increases Intestinal Lipid Absorption and Chylomicron Production via CD36
References
- Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation. 1999;100:723–728
- Detection of apolipoproteins B-48 and B-100 carrying particles in lipoprotein fractions extracted from human aortic atherosclerotic plaques in sudden cardiac death cases. Clin Chim Acta. 2008;390:38–43
- . Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia. 2003;46:733–749
- Cholesterol metabolism in type 1 diabetes. Diabetes. 2004;53:2217–2222
- . A proposed model for the assembly of chylomicrons. Atherosclerosis. 2000;148:1–15
- . Intestinal assembly and secretion of highly dense/lipid-poor apolipoprotein B48-containing lipoprotein particles in the fasting state: evidence for induction by insulin resistance and exogenous fatty acids. Metabolism. 2005;54:689–697
- Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine. Diabetes. 2006;55:1316–1326
- Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance (Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction). J Biol Chem. 2002;277:31646–31655
- Cellular aspects of intestinal lipoprotein assembly in Psammomys obesus: a model of insulin resistance and type 2 diabetes. Diabetes. 2003;52:2539–2545
- . Glucagon-like peptide-2. Annu Rev Nutr. 2006;26:391–411
- Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Gastroenterology. 2000;119:744–755
- GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006;130:150–164
- GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regul Pept. 2005;124:105–112
- The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat Med. 2000;6:802–807
- . The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways. Mol Endocrinol. 2005;19:459–473
- The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice. Gastroenterology. 2006;131:589–605
- . Up-regulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo. Am J Physiol. 1997;273:R1965–R1971
- Rapid insertion of GLUT2 into the rat jejunal brush-border membrane promoted by glucagon-like peptide 2. Biochem J. 2002;367:247–254
- Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1. Endocrinology. 2001;142:1148–1155
- Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans. Gastroenterology. 2006;130:44–54
- Tumor necrosis factor-α induces intestinal insulin resistance and stimulates the overproduction of intestinal apolipoprotein B48-containing lipoproteins. Diabetes. 2007;56:450–461
- CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem. 2007;282:19493–19501
- Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2. Am J Physiol. 1997;272:E1050–E1058
- Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects. Regul Pept. 2008;146:310–320
- Identification of the major intestinal fatty acid transport protein. Mol Cell. 1999;4:299–308
- Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci. 2006;119:4678–4688
- CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest. 2005;115:1290–1297
- CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology. 2006;131:1197–1207
- Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake. J Lipid Res. 2007;48:528–542
- Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes. 2002;51:3113–3119
- A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem. 1999;274:19055–19062
- CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance. J Lipid Res. 2005;46:2175–2181
- CD36 and proteoglycan-mediated pathways for (n-3) fatty acid enriched triglyceride-rich particle blood clearance in mouse models in vivo and in peritoneal macrophages in vitro. J Nutr. 2008;138:257–261
- FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell. 2005;16:24–31
- Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. J Biol Chem. 2002;277:16470–16477
- Glucagon-like peptide-2 relaxes mouse stomach through vasoactive intestinal peptide release. Am J Physiol Gastrointest Liver Physiol. 2009;296:G678–G684
- GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat. Regul Pept. 2002;107:129–135
- Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats. Am J Physiol. 1997;273:E815–E820
- The role of microsomal triglyceride transfer protein and dietary cholesterol in chylomicron production in diabetes. Diabetologia. 1999;42:944–948
Conflicts of interest The authors disclose the following: Daniel J. Drucker (Dr Drucker is a party to a licensing agreement among the University of Toronto, the University Health Network, and NPS Pharmaceuticals Inc in regard to the clinical development of GLP-2). The remaining authors disclose no conflicts.
Funding Supported by CIHR grant MOP-53093 (to K.A.) and CIHR grant MOP-14799 (to D.J.D.). J.H. is supported by the NSERC CGS M, Restracomp, and CIHR CGS D fellowships.
PII: S0016-5085(09)00868-3
doi: 10.1053/j.gastro.2009.05.051
© 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 137, Issue 3
, Pages 997-1005.e4
, September 2009

