Gastroenterology
Volume 137, Issue 3 , Pages 834-840.e3, September 2009

Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease

  • Jihane Romanos

      Affiliations

    • Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Cleo C. van Diemen

      Affiliations

    • Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Ilja M. Nolte

      Affiliations

    • Department of Epidemiology, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Gosia Trynka

      Affiliations

    • Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Alexandra Zhernakova

      Affiliations

    • Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, The Netherlands
    • ,
  • Jingyuan Fu

      Affiliations

    • Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • Department of Epidemiology, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Maria Teresa Bardella

      Affiliations

    • Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    • Department of Medical Sciences, University of Milan, Italy
    • ,
  • Donatella Barisani

      Affiliations

    • Department of Experimental Medicine, Faculty of Medicine University of Milano-Bicocca, Monza, Italy
    • ,
  • Ross McManus

      Affiliations

    • Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    • ,
  • David A. van Heel

      Affiliations

    • Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    • ,
  • Cisca Wijmenga

      Affiliations

    • Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands
    • Corresponding Author InformationReprint requests Address requests for reprints to: Cisca Wijmenga, PhD, Department of Genetics, University Medical Centre Groningen, PO Box 30001, 9700 RB, Groningen, the Netherlands. fax: +31-(0)50-361 7230

Received 17 February 2009; accepted 13 May 2009. published online 18 May 2009.

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    •  Conflicts of interest The authors disclose the following: David A. van Heel, Cisca Wijmenga and Ross McManus declare competing financial interests. A patent application by Queen Mary University of London is in progress. The remaining authors disclose no conflicts.

     Funding Supported by grants from the Celiac Disease Consortium (an innovative cluster approved by the Netherlands Genomics Initiative and partly funded by the Dutch Government, grant BSIK03009 to CW), the Netherlands Organisation for Scientific Research (NWO-VICI grant 918.66.620 to CW) and KP6 EU grant 036383 (PREVENTCD).

     To view this article's video abstract, go to the AGA's YouTube Channel.

    PII: S0016-5085(09)00772-0

    doi:10.1053/j.gastro.2009.05.040

    Gastroenterology
    Volume 137, Issue 3 , Pages 834-840.e3, September 2009