Gastroenterology
Volume 137, Issue 2 , Pages 673-681 , August 2009

Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry

  • Takuya Matsumura

      Affiliations

    • Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    • ,
  • Zongyi Hu

      Affiliations

    • Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    • ,
  • Takanobu Kato

      Affiliations

    • Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    • ,
  • Marlene Dreux

      Affiliations

    • Universite de Lyon, INSERM U758, and Ecole Normale Superieure de Lyon, Lyon, France
    • ,
  • Yong–Yuan Zhang

      Affiliations

    • Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    • ,
  • Michio Imamura

      Affiliations

    • Department of Medicine and Molecular Science, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    • ,
  • Nobuhiko Hiraga

      Affiliations

    • Department of Medicine and Molecular Science, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    • ,
  • Jean–Marc Juteau

      Affiliations

    • REPLICor Inc, Laval, Quebec, Canada
    • ,
  • Francois–Loic Cosset

      Affiliations

    • Universite de Lyon, INSERM U758, and Ecole Normale Superieure de Lyon, Lyon, France
    • ,
  • Kazuaki Chayama

      Affiliations

    • Department of Medicine and Molecular Science, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    • ,
  • Andrew Vaillant

      Affiliations

    • REPLICor Inc, Laval, Quebec, Canada
    • ,
  • T. Jake Liang

      Affiliations

    • Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    • Corresponding Author InformationReprint requests Address requests for reprints to: T. Jake Liang, MD, LDB/NIDDK/NIH, Bldg 10-9B16, 10 Center Dr, Bethesda, Maryland. fax: (301) 402-0491

Received 28 December 2008 ,Accepted 16 April 2009.

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 Conflicts of interest The authors diclose the following: J.–M.J. and A.V. are employees of REPLICor, Inc. The remaining authors disclose no conflicts.

 Funding Supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, NIH, and a NIH Cooperative Research and Development Agreement (DK-06-0367) between NIDDK and REPLICor, Inc.

PII: S0016-5085(09)00603-9

doi: 10.1053/j.gastro.2009.04.048

Gastroenterology
Volume 137, Issue 2 , Pages 673-681 , August 2009

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