Gastroenterology
Volume 137, Issue 2 , Pages 489-494.e1 , August 2009

Increased Colorectal Cancer Incidence in Obligate Carriers of Heterozygous Mutations in MUTYH

  • Natalie Jones

      Affiliations

    • Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom
    • ,
  • Stefanie Vogt

      Affiliations

    • Institute of Human Genetics, University of Bonn, Bonn, Germany
    • ,
  • Maartje Nielsen

      Affiliations

    • Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Daria Christian

      Affiliations

    • Institute of Human Genetics, University of Bonn, Bonn, Germany
    • ,
  • Petra A. Wark

      Affiliations

    • Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    • ,
  • Diana Eccles

      Affiliations

    • Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom
    • ,
  • Emma Edwards

      Affiliations

    • Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom
    • ,
  • D. Gareth Evans

      Affiliations

    • Academic Unit of Medical Genetics, Regional Genetic Service, St Mary's Hospital, Manchester, United Kingdom
    • ,
  • Eamonn R. Maher

      Affiliations

    • Department of Medical and Molecular Genetics, University of Birmingham, Birmingham, United Kingdom
    • ,
  • Hans F. Vasen

      Affiliations

    • Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Frederik J. Hes

      Affiliations

    • Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Stefan Aretz

      Affiliations

    • Institute of Human Genetics, University of Bonn, Bonn, Germany
    • ,
  • Julian R. Sampson

      Affiliations

    • Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom
    • Corresponding Author InformationReprint requests Address requests for reprints to: J. R. Sampson, MD, Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom. fax: (44) 2920 746551

Received 13 February 2009 ,Accepted 10 April 2009.

References 

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 This article has an accompanying continuing medical education activity on page 725. Learning Objective: Upon completion of this exam, successful learners will be able to identify the main colorectal phenotypic features and genetic characteristics of MUTYH-associated polyposis.

 Conflicts of interest The authors disclose the following: J. R. Sampson has previously made intellectual property rights applications in relation to MUTYH sequence variants. The remaining authors disclose no conflicts.

 Funding Supported in part by Cancer Research Wales, the Wales Office of Research and Development through the Wales Gene Park, German Cancer Aid (Deutsche Krebshilfe e.V. Bonn, grant No. 106244) and the Dutch Digestive Diseases Foundation (grant No. MWO 0355).

PII: S0016-5085(09)00560-5

doi: 10.1053/j.gastro.2009.04.047

Gastroenterology
Volume 137, Issue 2 , Pages 489-494.e1 , August 2009

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