Gastroenterology
Volume 136, Issue 5 , Pages 1680-1688.e7 , May 2009

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

  • Patty Trobridge

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Sue Knoblaugh

      Affiliations

    • Experimental Histopathology, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • M. Kay Washington

      Affiliations

    • Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee
    • ,
  • Nina M. Munoz

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Karen D. Tsuchiya

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • Department of Laboratory Medicine, University of Washington Medical School, Seattle, Washington
    • Department of Laboratories, Seattle Children's Hospital, Seattle, Washington
    • ,
  • Andres Rojas

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • Cancer Biology Department, Nashville, Tennessee
    • ,
  • Xiaoling Song

      Affiliations

    • Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Cornelia M. Ulrich

      Affiliations

    • Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Takehiko Sasazuki

      Affiliations

    • Department of Cell Biology, School of Medicine Fukuoka University, Fukuoka, Japan
    • ,
  • Senji Shirasawa

      Affiliations

    • Department of Cell Biology, School of Medicine Fukuoka University, Fukuoka, Japan
    • ,
  • William M. Grady

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • Department of Veterans Affairs R&D Service, Puget Sound Healthcare System, Seattle, Washington
    • Department of Medicine, University of Washington Medical School, Seattle, Washington
    • Corresponding Author InformationReprint requests Address requests for reprints to: William M. Grady, MD, Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Ave N, D4-100, Seattle, Washington 98109. fax: (206) 667-2917

Received 5 August 2008 ,Accepted 29 January 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by NCI RO1CA115513, Presidential Early Career Award for Scientists and Engineers (R&D Service, Department of Veterans Affairs; to W.M.G.), and 5 P30 CA015704.

PII: S0016-5085(09)00170-X

doi: 10.1053/j.gastro.2009.01.066

Gastroenterology
Volume 136, Issue 5 , Pages 1680-1688.e7 , May 2009

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