Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial

 J.G.A. and A.A. contributed equally to this work and share first authorship.

 Conflicts of interest The authors disclose no conflicts. The statistical analysis of the entire data sets pertaining to efficacy (specifically primary and major secondary efficacy end points) and safety (specifically serious adverse events as defined in federal guidelines) have been confirmed independently by a biostatistician (Juan G. Abraldes, MD) who is not employed by the corporate entity. The corresponding author had full access to all of the data and takes full responsibility for the veracity of the data and analysis.

 Funding Supported by Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, and the Spanish Ministry of Science and Innovation (grants CM0300123, 05/1285, 05/0519, and 06/0623). The Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas is funded by the Instituto de Salud Carlos III. The trial sponsor had no involvement in the design of the trial, collection and analysis of the data, or writing of the report.

 Trial registration number: NCT00594191.

PII: S0016-5085(09)00144-9

doi: 10.1053/j.gastro.2009.01.043

© 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.