Gastroenterology
Volume 136, Issue 3 , Pages 763-766 , March 2009

Bak to Basics of Colonocyte Renewal

  • Nathan J. Susnow

      Affiliations

    • Gastroenterology/Hepatology Division, Department of Medicine, University of Washington, Seattle, Washington
    • Corresponding Author InformationReprint requests Address requests for reprints to: Nathan J. Susnow, MD, Gastroenterology/Hepatology Division, Department of Medicine, University of Washington, Box 356424, Suite AA103, 1959 NE Pacific Street, Seattle, Washington 98195-6424. fax: (206) 764-2147
    • ,
  • David M. Hockenbery

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington

  • Image Result

    Distribution of primary regulators of apoptosis within colon crypts. As cells migrate outward from the crypt base, Bak expression is maximal at the crypt table and lower crypt, while Bcl-2 is confined

    Distribution of primary regulators of apoptosis within colon crypts. As cells migrate outward from the crypt base, Bak expression is maximal at the crypt table and lower crypt, while Bcl-2 is confined to basal cell positions.

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)00051-1

doi: 10.1053/j.gastro.2009.01.021

Gastroenterology
Volume 136, Issue 3 , Pages 763-766 , March 2009

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