Gastroenterology
Volume 137, Issue 1 , Pages 231-241.e10 , July 2009

Delineation of the Chemomechanosensory Regulation of Gastrin Secretion Using Pure Rodent G Cells

  • Mark Kidd

      Affiliations

    • Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Øyvind Hauso

      Affiliations

    • Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut
    • St Olav's Hospital HF, Trondheim University Hospital, Trondheim, Norway
    • ,
  • Ignat Drozdov

      Affiliations

    • Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Bjorn I. Gustafsson

      Affiliations

    • Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut
    • St Olav's Hospital HF, Trondheim University Hospital, Trondheim, Norway
    • Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Irvin M. Modlin

      Affiliations

    • Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut
    • Corresponding Author InformationReprint requests Address requests for reprints to: Irvin M. Modlin, MD, PhD, DSc, FRCS (Eng & Ed), Department of Gastroenterological Surgery, Yale University School of Medicine, 333 Cedar Street, PO Box 208062, New Haven, Connecticut 06520-8062. fax: (203) 737-4067

Received 15 August 2008 ,Accepted 8 January 2009.

References 

  1. Modlin IM, Kidd M, Marks IN, et al. The pivotal role of John S. Edkins in the discovery of gastrin. World J Surg. 1997;21:226–234
  2. Modlin I, Sachs G. Acid related diseases: biology and treatment. Lippincott, Williams and Wilkins; 2004;
  3. Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology. 2008;134:1842–1860
  4. Kidd M, Modlin IM, Tang LH. Gastrin and the enterochromaffin-like cell: an acid update. Dig Surg. 1998;15:209–217
  5. Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A. 2007;104:15069–15074
  6. Kidd M, Modlin I, Gustafsson B, et al. The luminal regulation of normal and neoplastic EC cell serotonin release is mediated by bile salts, amines, tastants and olfactants. Am J Physiol. 2008;295:G260–G272
  7. Lehmann FS, Schiller N, Cover T, et al. H pylori stimulates gastrin release from canine antral cells in primary culture. Am J Physiol. 1998;274:G992–G996
  8. Kidd M, Modlin IM, Black JW, et al. A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Regul Pept. 2007;143:109–117
  9. Kidd M, Modlin IM, Eick GN, et al. Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development. Am J Physiol Gastrointest Liver Physiol. 2007;292:G191–G200
  10. Kidd M, Modlin I, Eick G, et al. Isolation, purification and functional characterization of the mastomys EC cell. Am J Physiol. 2006;291:G778–G791
  11. Polak J, Pearse A, Heath C. Complete identification of endocrine cells in the gastrointestinal tract: use of the semithin-thin section technique to identify motilin cells in human and animal tissue. Gut. 1976;16:225–229
  12. Forssmann WG, Orci L, Pictet R, et al. The endocrine cells in the epithelium of the gastrointestinal mucosa of the rat (An electron microscope study). J Cell Biol. 1969;40:692–715
  13. Yiu WK, Cheng SW, Sumpio BE. Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming. J Vasc Surg. 2007;46:557–564
  14. Kidd M, Schally AV, Pfragner R, et al. Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors. Cancer. 2008;112:1404–1414
  15. Shurety W, Stewart NL, Stow JL. Fluid-phase markers in the basolateral endocytic pathway accumulate in response to the actin assembly-promoting drug Jasplakinolide. Mol Biol Cell. 1998;9:957–975
  16. Kidd M, Hinoue T, Eick G, et al. Global expression analysis of ECL cells in Mastomys natalensis gastric mucosa identifies alterations in the AP-1 pathway induced by gastrin-mediated transformation. Physiol Genomics. 2004;20:131–142
  17. Kidd M, Miu K, Tang LH, et al. Helicobacter pylori lipopolysaccharide stimulates histamine release and DNA synthesis in rat enterochromaffin-like cells. Gastroenterology. 1997;113:1110–1117
  18. Kidd M, Eick GN, Modlin IM, et al. Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and rapamycin. J Mol Endocrinol. 2007;38:181–192
  19. Coates MD, Mahoney CR, Linden DR, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 2004;126:1657–1664
  20. Itoh Z, Nakaya M, Suzuki T, et al. Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am J Physiol. 1984;247:G688–G694
  21. Metz DC, Buchanan M, Purich E, et al. A randomized controlled crossover study comparing synthetic porcine and human secretins with biologically derived porcine secretin to diagnose Zollinger-Ellison Syndrome. Aliment Pharmacol Ther. 2001;15:669–676
  22. Beales I, Blaser MJ, Srinivasan S, et al. Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G cells. Gastroenterology. 1997;113:465–471
  23. Sugano K, Park J, Soll AH, et al. Stimulation of gastrin release by bombesin and canine gastrin-releasing peptides (Studies with isolated canine G cells in primary culture). J Clin Invest. 1987;79:935–942
  24. Lehy T, Mignon M, Cadiot G, et al. Gastric endocrine cell behavior in Zollinger-Ellison patients upon long-term potent antisecretory treatment. Gastroenterology. 1989;96:1029–1040
  25. Inoue M, Glendinning JI, Theodorides ML, et al. Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice. Physiol Genomics. 2007;32:82–94
  26. Kechagias S, Botella S, Petersson F, et al. Expression of vanilloid receptor-1 in epithelial cells of human antral gastric mucosa. Scand J Gastroenterol. 2005;40:775–782
  27. Ericson A, Nur EM, Petersson F, et al. The effects of capsaicin on gastrin secretion in isolated human antral glands: before and after ingestion of red chilli. Dig Dis Sci. 2009;54:491–498
  28. Wu SV, Rozengurt N, Yang M, et al. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci U S A. 2002;99:2392–2397
  29. Rozengurt E. Taste receptors in the gastrointestinal tract (I. Bitter taste receptors and alpha-gustducin in the mammalian gut). Am J Physiol Gastrointest Liver Physiol. 2006;291:G171–G177
  30. Prinz C, Scott D, Herwitz D, et al. Gastrin effects on isolated rat enterochromaffin-like cells in primary culture. Am J Physiol. 1994;267:G663–G676
  31. Varkevisser B, Kinnamon SC. Sweet taste transduction in hamster: role of protein kinases. J Neurophysiol. 2000;83:2526–2532
  32. Mace OJ, Lister N, Morgan EL, et al. An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol. 2009;587:195–210
  33. Schmausser B, Andrulis M, Endrich S, et al. Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol. 2004;136:521–526
  34. Beales IL, Calam J. Helicobacter pylori increases gastrin release from cultured canine antral G-cells. Eur J Gastroenterol Hepatol. 2000;12:641–644
  35. Kidd M, Gustafsson BI, Drozdov I, et al. IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease. Neurogastroenterol Motil. 2008;Oct 25 [Epub ahead of print].
  36. Li X, Commane M, Jiang Z, et al. IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc Natl Acad Sci U S A. 2001;98:4461–4465
  37. Tennant SM, Hartland EL, Phumoonna T, et al. Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infect Immun. 2008;76:639–645
  38. Raybould H, Cooke H, Christof F. Sensory mechanisms: transmitters, modulators and reflexes. Neurogastroenterol Motil. 2004;16(Suppl 1):60–63
  39. Schepp W, Soll AH, Walsh JH. Dual modulation by adenosine of gastrin release from canine G-cells in primary culture. Am J Physiol. 1990;259:G556–G563
  40. Kidd M, Gustafsson B, Drozdov I, et al. Regulation of small intestinal EC cell serotonin release—the role of taste and mechanical forces. Gastroenterology. 2008;134:373

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by the Norwegian Research Council, the Oddrun Mjåland Foundation, and the Bruggeman Medical Foundation.

PII: S0016-5085(09)00011-0

doi: 10.1053/j.gastro.2009.01.005

Gastroenterology
Volume 137, Issue 1 , Pages 231-241.e10 , July 2009

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