Gastroenterology
Volume 136, Issue 4 , Pages 1198-1205 , April 2009

A Population-Based Study of Perforated Diverticular Disease Incidence and Associated Mortality

  • David J. Humes

      Affiliations

    • Wolfson Digestive Disease Centre, Nottingham University Hospital NHS Trust, Nottingham
    • Corresponding Author InformationReprint requests Address requests for reprints to: David Humes, Royal College of Surgeons and Research into Ageing Research Fellow, Wolfson Digestive Disease Centre, QMC Campus, C Floor, South Block, Nottingham University Hospital NHS Trust, Derby Road Nottingham NG7 2UH, United Kingdom. fax: (11) 5823 1160
    • ,
  • Masoud Solaymani–Dodaran

      Affiliations

    • Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom
    • ,
  • Kate M. Fleming

      Affiliations

    • Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom
    • ,
  • John Simpson

      Affiliations

    • Wolfson Digestive Disease Centre, Nottingham University Hospital NHS Trust, Nottingham
    • ,
  • Robin C. Spiller

      Affiliations

    • Wolfson Digestive Disease Centre, Nottingham University Hospital NHS Trust, Nottingham
    • ,
  • Joe West

      Affiliations

    • Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom

Received 12 May 2008 ,Accepted 11 December 2008.

References 

  1. http://www.statistics.gov.uk/STATBASE/Expodata/Spreadsheets/D6922.xls
  2. Makela J, Kiviniemi H, Laitinen S. Prevalence of perforated sigmoid diverticulitis is increasing. Dis Colon Rectum. 2002;45:955–961
  3. Kang JY, Hoare J, Tinto A, et al. Diverticular disease of the colon—on the rise: a study of hospital admissions in England between 1989/1990 and 1999/2000. Aliment Pharmacol Ther. 2003;17:1189–1195
  4. Hall KE, Proctor DD, Fisher L, et al. American Gastroenterological Association Future Trends Committee Report: effects of aging of the population on gastroenterology practice, education, and research. Gastroenterology. 2005;129:1305
  5. Hart AR, Kennedy HJ, Stebbings WS, et al. How frequently do large bowel diverticula perforate? (An incidence and cross-sectional study). Eur J Gastroenterol Hepatol. 2000;12:661–665
  6. Morris CR, Harvey IM, Stebbings WSL, et al. Incidence of perforated diverticulitis and risk factors for death in a UK population. Br J Surg. 2008;95:876–881
  7. Constantinides VA, Tekkis PP, Senapati A. Prospective multicentre evaluation of adverse outcomes following treatment for complicated diverticular disease. Br J Surg. 2006;93:1503–1513
  8. Salem L, Anaya DA, Roberts KE, et al. Hartmann's colectomy and reversal in diverticulitis: a population-level assessment. Dis Colon Rectum. 2005;48:988–995
  9. Krukowski ZH, Matheson NA. Emergency surgery for diverticular disease complicated by generalized and faecal peritonitis: a review. Br J Surg. 1984;71:921–927
  10. Ferzoco LB, Raptopoulos V, Silen W. Acute diverticulitis. N Engl J Med. 1998;338:1521–1526
  11. Lewis JD, Bilker WB, Weinstein RB, et al. The relationship between time since registration and measured incidence rates in the General Practice Research Database. Pharmacoepidemiol Drug Saf. 2005;14:443–451
  12. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383
  13. Bennett-Guerrero E, Hyam JA, Shaefi S, et al. Comparison of P-POSSUM risk-adjusted mortality rates after surgery between patients in the USA and the UK. Br J Surg. 2003;90:1593–1598
  14. Dawwas MF, Gimson AE, Lewsey JD, et al. UKaILTA Survival after liver transplantation in the United Kingdom and Ireland compared with the United States. Gut. 2007;56:1606–1613
  15. Morris CR, Harvey IM, Stebbings WSL, et al. Anti-inflammatory drugs, analgesics and the risk of perforated colonic diverticular disease. Br J Surg. 2003;90:1267–1272
  16. Tudor RG, Farmakis N, Keighley MR. National audit of complicated diverticular disease: analysis of index cases. Br J Surg. 1994;81:730–732
  17. Roche JJ, Wenn RT, Sahota O, et al. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331:1374–1378

 Conflicts of Interest The authors disclose no conflicts.

 Funding Supported by a Research Fellowship from The Royal College of Surgeons of England and Research into Ageing (to D.J.H.), by a National Institute of Health Research/Department of Health Clinician Scientist Fellowship (to J.W. and K.F.), the Medical Research Council scheme for academic use of GPRD data for the data set, and by the Mason Medical Foundation and the University of Nottingham Institute of Clinical Research for the validation study.

PII: S0016-5085(08)02312-3

doi: 10.1053/j.gastro.2008.12.054

Gastroenterology
Volume 136, Issue 4 , Pages 1198-1205 , April 2009

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