Gastroenterology
Volume 136, Issue 2 , Pages 396-399 , February 2009

Exposed: The Genetic Underpinnings of Ulcerative Colitis Relative to Crohn's Disease

  • Steven R. Brant, M.D.

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Steven R. Brant, M.D., Meyerhoff IBD Center, Johns Hopkins University, 1501 E. Jefferson St., B136, Baltimore, MD 21231

References 

  1. Orholm M, Iselius L, Sorensen TI, et al. Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis. BMJ. 1993;306:20–24
  2. Brant SR, Shugart YY. Inflammatory bowel disease gene hunting by linkage analysis: rationale, methodology, and present status of the field. Inflamm Bowel Dis. 2004;10:300–311
  3. Anderson CA, Massey DCO, Barrett JC, et al. Investigation of Crohn's disease risk loci in Ulcerative Colitis further defines their molecular relationship. Gastroenterology. 2009;136:523–529
  4. Cho JH, Weaver CT. The genetics of inflammatory bowel disease. Gastroenterology. 2007;133:1327–1339
  5. Fisher SA, Tremelling M, Anderson CA, et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet. 2008;40:710–712
  6. Raelson JV, Little RD, Ruether A, et al. Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A. 2007;104:14747–14752
  7. Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 2008;40:1319–1323
  8. Kugathasan S, Baldassano RN, Bradfield JP, et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet. 2008;40:1211–1215
  9. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease. Nat Genet. 2008;40:955–962
  10. Franke A, Balschun T, Karlsen TH, et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet. 2008;40:713–715
  11. Silverberg MS, Cho JH, Rioux JD, et al. Ulcerative colitis loci on chromosomes 1p36 and 12q15 identified by genome-wide association study. Nat Genet. 2009;Jan 4; [Epub ahead of print]

 The author discloses no conflicts.

PII: S0016-5085(08)02193-8

doi: 10.1053/j.gastro.2008.12.016

Gastroenterology
Volume 136, Issue 2 , Pages 396-399 , February 2009

Article Tools

* Image Usage & Resolution