Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

Anderson, Carl A.; Massey, Dunecan C.O.; Barrett, Jeffrey C.; Prescott, Natalie J.; Tremelling, Mark; Fisher, Sheila A.; Gwilliam, Rhian; Jacob, Jemima; Nimmo, Elaine R.; Drummond, Hazel; Lees, Charlie W.; Onnie, Clive M.; Hanson, Catherine; Blaszczyk, Katarzyna; Ravindrarajah, Radhi; Hunt, Sarah; Varma, Dhiraj; Hammond, Naomi; Lewis, Gregory; Attlesey, Heather; Watkins, Nick; Ouwehand, Willem; Strachan, David; McArdle, Wendy; Lewis, Cathryn M.; The Wellcome Trust Case Control Consortium,; Lobo, Alan; Sanderson, Jeremy; Jewell, Derek P.; Deloukas, Panos; Mansfield, John C.; Mathew, Christopher G.; Satsangi, Jack; Parkes, Miles

doi:10.1053/j.gastro.2008.10.032

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Volume 136, Issue 2 , Pages 523-529.e3, February 2009

Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

Carl A. Anderson
- Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford
Dunecan C.O. Massey
- Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge
Jeffrey C. Barrett
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
Natalie J. Prescott
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
Mark Tremelling
- Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge
Sheila A. Fisher
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
Rhian Gwilliam
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
Jemima Jacob
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
Elaine R. Nimmo
- Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh
Hazel Drummond
- Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh
Charlie W. Lees
- Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh
Clive M. Onnie
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
Catherine Hanson
- Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne
Katarzyna Blaszczyk
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
Radhi Ravindrarajah
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
Sarah Hunt
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
Dhiraj Varma
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
Naomi Hammond
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
Gregory Lewis
- Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge
Heather Attlesey
- Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge
Nick Watkins
- Department of Haematology, University of Cambridge, National Blood Service Centre, Long Road, Cambridge
Willem Ouwehand
- Department of Haematology, University of Cambridge, National Blood Service Centre, Long Road, Cambridge
David Strachan
- Division of Community Health Services, St. George's University of London, Cranmer Terrace, London
Wendy McArdle
- ALSPAC, Dept Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol
Cathryn M. Lewis
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
The Wellcome Trust Case Control Consortium
Alan Lobo
- Division of Molecular and Genetic Medicine, University of Sheffield Medical School, Royal Hallamshire Hospital, Sheffield
Jeremy Sanderson
- Department of Gastroenterology, Guy's and St. Thomas' NHS Foundation Trust, London
Derek P. Jewell
- Gastroenterology Unit, Radcliffe Infirmary, University of Oxford, Oxford, United Kingdom
Panos Deloukas
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
John C. Mansfield
- Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne
Christopher G. Mathew
- Department of Medical and Molecular Genetics, King's College London School of Medicine, London
Jack Satsangi
- Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh
Miles Parkes
- Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge
- Address requests for reprints to: Miles Parkes, Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom

Received 2 September 2008; accepted 16 October 2008. published online 28 October 2008.

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C.A.A. and D.C.O.M. contributed equally to this work.

The authors disclose the following: Supported by the NIHR Cambridge Biomedical Research Centre, by the Wellcome Trust (to C.A.A.), and by the Medical Research Council (to D.C.O.M.).

PII: S0016-5085(08)01867-2

doi:10.1053/j.gastro.2008.10.032

Refers to article:

Exposed: The Genetic Underpinnings of Ulcerative Colitis Relative to Crohn's Disease , 05 January 2009
Steven R. Brant
Gastroenterology February 2009 (Vol. 136, Issue 2, Pages 396-399)
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