Gastroenterology
Volume 136, Issue 1 , Pages 131-137 , January 2009

Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome

  • Juul T. Wijnen

      Affiliations

    • Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    • Department of Clinical Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Richard M. Brohet

      Affiliations

    • Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    • Department of Research and Education, Spaarne Hospital, Hoofddorp, The Netherlands
    • ,
  • Ronald van Eijk

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Shanty Jagmohan–Changur

      Affiliations

    • Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Anneke Middeldorp

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Carli M. Tops

      Affiliations

    • Department of Clinical Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Mario van Puijenbroek

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Margreet G.E.M. Ausems

      Affiliations

    • Department of Medical Genetics, Academic Medical Centre Utrecht, Utrecht, The Netherlands
    • ,
  • Encarna Gómez García

      Affiliations

    • Departments of Clinical Genetics, and Research Institute Growth & Development (GROW), University of Maastricht, The Netherlands
    • ,
  • Frederik J. Hes

      Affiliations

    • Department of Clinical Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Nicoline Hoogerbrugge

      Affiliations

    • Department of Clinical Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    • ,
  • Fred H. Menko

      Affiliations

    • Department of Clinical Genetics, VU University Hospital, Amsterdam, The Netherlands
    • ,
  • Theo A.M. van Os

      Affiliations

    • Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Rolf H. Sijmons

      Affiliations

    • Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Senno Verhoef

      Affiliations

    • Family Cancer Clinic, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Anja Wagner

      Affiliations

    • Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Fokko M. Nagengast

      Affiliations

    • Department of Gastroenterology and Hepatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    • ,
  • Jan H. Kleibeuker

      Affiliations

    • Department of Gastroenterology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Peter Devilee

      Affiliations

    • Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Hans Morreau

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • David Goldgar

      Affiliations

    • Department of Dermatology, University of Utah School of Medicine, Salt Lake City
    • ,
  • Ian P. Tomlinson

      Affiliations

    • Molecular and Population Genetics Laboratory, Cancer Research UK London Research Institute, London, England
    • ,
  • Richard S. Houlston

      Affiliations

    • Section of Cancer Genetics, Institute of Cancer Research, Sutton, England
    • ,
  • Tom van Wezel

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Hans F.A. Vasen

      Affiliations

    • Department of Gastroenterology and Hepatology, Leiden University Medical Centre and The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    • Corresponding Author InformationAddress requests for reprints to: Hans F. A. Vasen, MD, PhD, Netherlands Foundation for the Detection of Hereditary Tumours, Poortgebouw Zuid, Rynsburgerweg 10, 2333 AA Leiden, The Netherlands. fax: +31 (0) 71 5212137

Received 4 July 2008 ,Accepted 18 September 2008.

References 

  1. Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003;348:919–932
  2. Krüger S, Engel C, Bier A, et al. German HNPCC Consortium (The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1). Cancer Lett. 2007;252:55–66
  3. Jones JS, Amos CI, Pande M, et al. DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset. Cancer Epidemiol Biomarkers Prev. 2006;15:886–891
  4. Zecevic M, Amos CI, Gu X, et al. IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst. 2006;98:139–143
  5. Campbell PT, Edwards L, McLaughlin JR, et al. Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland. Clin Cancer Res. 2007;13:3783–3788
  6. Tomlinson I, Webb E, Carvajal-Carmona L, et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet. 2007;39:984–988
  7. Zanke BW, Greenwood CM, Rangrej J, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet. 2007;39:989–994
  8. Haiman CA, Patterson N, Freedman ML, et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007;39:638–644
  9. Broderick P, Carvajal-Carmona L, Pittman AM, et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet. 2007;39:1315–1317
  10. Jaeger E, Webb E, Howarth K, et al. Common genetic variants at the HMPS/CRAC1 locus on chromosome 15q13.3 influence the risk of colorectal cancer in the UK population. Nat Genet. 2008;40:26–28
  11. Tomlinson IP, Webb E, Carvajal-Carmona L, et al. A genome-wide association study identifies novel colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet. 2008;40:623–630
  12. Tenesa A, Farrington SM, Prendergast JG, et al. A genome-wide association scan identifies a new colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet. 2008;40:630–637
  13. Quehenberger F, Vasen HF, van Houwelingen HC. Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment. J Med Genet. 2005;42:491–496
  14. Antoniou AC, Goldgar DE, Andrieu N, et al. A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet Epidemiol. 2005;29:1–11
  15. Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med. 1998;21:1481–1487
  16. Savinainen KJ, Linja MJ, Saramäki OR, et al. Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer. Br J Cancer. 2004;90:1041–1046
  17. Okamoto H, Yasui K, Zhao C, et al. PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Hepatology. 2003;38:1242–1249
  18. Zhao C, Inoue J, Imoto I, et al. POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17. Oncogene. 2008;27:63–75

 The authors disclose the following: The study was partly funded with a Dutch Cancer Society Grant UL2005-3247 to T.W., J.T.W., and H.M.

 Contributors: J.T.W., R.M.B., I.P.T., R.S.H., T.W., P.D., H.M., and H.F.V. conceived the idea for the relevant analyses and drafted the manuscript. R.E., S.J.C., A.M., and M.P. were responsible for the SNP analyses. R.M.B. and D.G. performed the statistical analyses. C.M.T., M.G.A., E.G.G., F.J.H., N.H., F.H.M., T.A.O., R.H.S., S.V., A.W., F.M.N., and J.H.K. provided clinical data and patient material. All authors critically reviewed the report and approved the final version.

PII: S0016-5085(08)01701-0

doi: 10.1053/j.gastro.2008.09.033

Gastroenterology
Volume 136, Issue 1 , Pages 131-137 , January 2009

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