Gastroenterology
Volume 136, Issue 1 , Pages 131-137 , January 2009

Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome

  • Juul T. Wijnen

      Affiliations

    • Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    • Department of Clinical Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Richard M. Brohet

      Affiliations

    • Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    • Department of Research and Education, Spaarne Hospital, Hoofddorp, The Netherlands
    • ,
  • Ronald van Eijk

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Shanty Jagmohan–Changur

      Affiliations

    • Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Anneke Middeldorp

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Carli M. Tops

      Affiliations

    • Department of Clinical Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Mario van Puijenbroek

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Margreet G.E.M. Ausems

      Affiliations

    • Department of Medical Genetics, Academic Medical Centre Utrecht, Utrecht, The Netherlands
    • ,
  • Encarna Gómez García

      Affiliations

    • Departments of Clinical Genetics, and Research Institute Growth & Development (GROW), University of Maastricht, The Netherlands
    • ,
  • Frederik J. Hes

      Affiliations

    • Department of Clinical Genetics, Leiden University Medical Centre, The Netherlands
    • ,
  • Nicoline Hoogerbrugge

      Affiliations

    • Department of Clinical Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    • ,
  • Fred H. Menko

      Affiliations

    • Department of Clinical Genetics, VU University Hospital, Amsterdam, The Netherlands
    • ,
  • Theo A.M. van Os

      Affiliations

    • Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Rolf H. Sijmons

      Affiliations

    • Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Senno Verhoef

      Affiliations

    • Family Cancer Clinic, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Anja Wagner

      Affiliations

    • Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Fokko M. Nagengast

      Affiliations

    • Department of Gastroenterology and Hepatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    • ,
  • Jan H. Kleibeuker

      Affiliations

    • Department of Gastroenterology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Peter Devilee

      Affiliations

    • Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Hans Morreau

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • David Goldgar

      Affiliations

    • Department of Dermatology, University of Utah School of Medicine, Salt Lake City
    • ,
  • Ian P. Tomlinson

      Affiliations

    • Molecular and Population Genetics Laboratory, Cancer Research UK London Research Institute, London, England
    • ,
  • Richard S. Houlston

      Affiliations

    • Section of Cancer Genetics, Institute of Cancer Research, Sutton, England
    • ,
  • Tom van Wezel

      Affiliations

    • Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    • ,
  • Hans F.A. Vasen

      Affiliations

    • Department of Gastroenterology and Hepatology, Leiden University Medical Centre and The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    • Corresponding Author InformationAddress requests for reprints to: Hans F. A. Vasen, MD, PhD, Netherlands Foundation for the Detection of Hereditary Tumours, Poortgebouw Zuid, Rynsburgerweg 10, 2333 AA Leiden, The Netherlands. fax: +31 (0) 71 5212137

Received 4 July 2008 ,Accepted 18 September 2008.

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 The authors disclose the following: The study was partly funded with a Dutch Cancer Society Grant UL2005-3247 to T.W., J.T.W., and H.M.

 Contributors: J.T.W., R.M.B., I.P.T., R.S.H., T.W., P.D., H.M., and H.F.V. conceived the idea for the relevant analyses and drafted the manuscript. R.E., S.J.C., A.M., and M.P. were responsible for the SNP analyses. R.M.B. and D.G. performed the statistical analyses. C.M.T., M.G.A., E.G.G., F.J.H., N.H., F.H.M., T.A.O., R.H.S., S.V., A.W., F.M.N., and J.H.K. provided clinical data and patient material. All authors critically reviewed the report and approved the final version.

PII: S0016-5085(08)01701-0

doi: 10.1053/j.gastro.2008.09.033

Gastroenterology
Volume 136, Issue 1 , Pages 131-137 , January 2009

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