Gastroenterology
Volume 136, Issue 1 , Pages 278-287, January 2009

CpG Motifs of Bacterial DNA Exert Protective Effects in Mouse Models of IBD by Antigen-Independent Tolerance Induction

  • Andre Bleich

      Affiliations

    • Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    • Corresponding Author InformationAddress requests for reprints to: Andre Bleich, Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. fax: +49 511 532 3710
    • ,
  • Lydia M. Janus

      Affiliations

    • Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    • ,
  • Anna Smoczek

      Affiliations

    • Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    • ,
  • Astrid M. Westendorf

      Affiliations

    • Department Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig, and Institute of Medical Microbiology, University Hospital Essen, Essen, Germany
    • ,
  • Ulrike Strauch

      Affiliations

    • Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    • ,
  • Michael Mähler

      Affiliations

    • Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    • ,
  • Hans-J. Hedrich

      Affiliations

    • Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    • ,
  • Stefan Fichtner-Feigl

      Affiliations

    • Department of Surgery, University of Regensburg, Regensburg, Germany
    • ,
  • Jürgen Schölmerich

      Affiliations

    • Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    • ,
  • Werner Falk

      Affiliations

    • Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    • ,
  • Claudia Hofmann

      Affiliations

    • Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    • ,
  • Florian Obermeier

      Affiliations

    • Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

Received 22 January 2008; accepted 18 September 2008. published online 26 September 2008.

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 C.H. and F.O. contributed equally to the work.

 The authors disclose the following: Supported by grants from the DFG (O.B. 135/10-1, F.O.; SFB621, H.H.) and the German Crohn′s and Colitis Foundation (DCCV, F.O.). The authors gratefully acknowledge the excellent technical assistance of N. Dunger.

PII: S0016-5085(08)01691-0

doi:10.1053/j.gastro.2008.09.022

Gastroenterology
Volume 136, Issue 1 , Pages 278-287, January 2009

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