Gastroenterology
Volume 135, Issue 6 , Pages 1935-1944.e1 , December 2008

Aminotransferase Levels and 20-Year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease

  • Wolfram Goessling

      Affiliations

    • Division of Genetics and Gastroenterology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
    • Corresponding Author InformationAddress requests for reprints to: Wolfram Goessling, MD, PhD, Genetics Division, Brigham and Women's Hospital, NRB 4-058, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115. fax: (617) 525-4751
    • ,
  • Joseph M. Massaro

      Affiliations

    • Department of Biostatistics, Boston University, Boston, Massachusetts
    • ,
  • Ramachandran S. Vasan

      Affiliations

    • The National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
    • Division of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
    • Division of Cardiology and Molecular Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
    • ,
  • Ralph B. D'Agostino Sr

      Affiliations

    • Department of Mathematics and Statistics, Boston University, Boston, Massachusetts
    • ,
  • R. Curtis Ellison

      Affiliations

    • Division of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
    • ,
  • Caroline S. Fox

      Affiliations

    • Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • The National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts

Received 28 February 2008 ,Accepted 4 September 2008.

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 The authors disclose the following: Supported by the National Heart, Lung, and Blood Institute's Framingham Heart Study (N01-HC-25195). W.G. is supported by K08-DK071940 (NIDDK/NIH). R.S.V. is supported in part by 2K24HL04334 (NHLBI/NIH). W.G. and C.S.F. designed and conducted the study, analyzed and interpreted the data, and prepared the manuscript. They had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. J.M.M. performed all the statistical analyses. All authors reviewed and approved the manuscript.

PII: S0016-5085(08)01683-1

doi: 10.1053/j.gastro.2008.09.018

Gastroenterology
Volume 135, Issue 6 , Pages 1935-1944.e1 , December 2008

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